Unsupervised detection of regulatory gene expression information in different genomic regions enables gene expression ranking

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• 作者：Zohar Zafrir ; Tamir Tuller
• 关键词：Gene expression ; Intron evolution ; Transcript evolution
• 刊名：BMC Bioinformatics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1645KB
• 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Algorithms;
• 出版者：BioMed Central
• ISSN：1471-2105
• 卷排序：18

文摘

BackgroundThe regulation of all gene expression steps (e.g., Transcription, RNA processing, Translation, and mRNA Degradation) is known to be primarily encoded in different parts of genes and in genomic regions in proximity to genes (e.g., promoters, untranslated regions, coding regions, introns, etc.). However, the entire gene expression codes and the genomic regions where they are encoded are still unknown.