Ethoxyfagaronine, a synthetic analogue of fagaronine that inhibits vascular endothelial growth factor-1, as a new anti-angiogeneic agent
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  • 作者:Farid Ouchani (1)
    Albin Jeanne (1)
    Jessica Thevenard (1)
    Jean-Jacques Helesbeux (2)
    Amandine Wahart (1)
    Isabelle Letinois (1)
    Olivier Duval (2)
    Laurent Martiny (1)
    Emmanuelle Charpentier (1)
    J茅r么me Devy (1)
  • 关键词:Ethoxyfagaronine ; Angiogenesis ; VEGF receptor ; FAK ; MT1 ; MMP
  • 刊名:Investigational New Drugs
  • 出版年:2015
  • 出版时间:February 2015
  • 年:2015
  • 卷:33
  • 期:1
  • 页码:75-85
  • 全文大小:9,020 KB
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    12. Messmer WM, Tin-Wa M, Fong HH, Bevelle C, Farnsworth NR, Abraham DJ et al (1972) Fagaronine, a new tumor inhibitor isolated from Fagara zanthoxyloides Lam. (Rutaceae). J Pharm Sci 61:1858鈥?859 CrossRef
    13. Comoe L, Jeannesson P, Trentesaux C, Desoize B, Jardillier JC (1987) The antileukemic alkaloid fagaronine and the human K 562 leukemic cells: effects on growth and induction of erythroid differentiation. Leuk Res 11:445鈥?51 CrossRef
    14. Stermitz FR, Larson KA, Kim DK (1973) Some structural relationships among cytotoxic and antitumor benzophenanthridine alkaloid derivatives. J Med Chem 16:939鈥?40 CrossRef
    15. Lynch MA, Duval O, Sukhanova A, Devy J, MacKay SP, Waigh RD et al (2001) Synthesis, biological activity and comparative analysis of DNA binding affinities and human DNA topoisomerase I inhibitory activities of novel 12-alkoxy-benzo[c]phenanthridinium salts. Bioorg Med Chem Lett 11:2643鈥?646 CrossRef
    16. Deroussent A, Re M, Hoellinger H, Vanquelef E, Duval O, Sonnier M et al (2004) In vitro metabolism of ethoxidine by human CYP1A1 and rat microsomes: identification of metabolites by high-performance liquid chromatography combined with electrospray tandem mass spectrometry and accurate mass measurements by time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 18:474鈥?82 CrossRef
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    18. Ouchani F, Devy J, Rusciani A, Helesbeux JJ, Salesse S, Letinois I et al (2012) Targeting focal adhesion assembly by ethoxyfagaronine prevents lymphoblastic cell adhesion to fibronectin. Anal Cell Pathol 35:267鈥?84 CrossRef
    19. Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I (2001) Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem J 360:255鈥?64 CrossRef
    20. Galvez BG, Matias-Roman S, Albar JP, Sanchez-Madrid F, Arroyo AG (2001) Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling. J Biol Chem 276:37491鈥?7500 CrossRef
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    22. Sallam TH, El Telbany MA, Mahmoud HM, Iskander MA (2013) Significance of neuropilin-1 expression in acute myeloid leukemia. Turk J Haematol 30:300鈥?06 CrossRef
    23. Ma J, Waxman DJ (2008) Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 7:3670鈥?684 CrossRef
    24. Thevenard J, Ramont L, Devy J, Brassart B, Dupont-Deshorgue A, Floquet N et al (2010) The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration. Int J Cancer J Int Du Cancer 126:1055鈥?066
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    30. Devy J, Ouchani F, Oudot C, Helesbeux JJ, Vanquelef E, Salesse S, et al (2010). The anti-invasive activity of synthetic alkaloid ethoxyfagaronine on L1210 leukemia cells is mediated by down-regulation of plasminogen activators and MT1-MMP expression and activity. Invest New Drugs
  • 作者单位:Farid Ouchani (1)
    Albin Jeanne (1)
    Jessica Thevenard (1)
    Jean-Jacques Helesbeux (2)
    Amandine Wahart (1)
    Isabelle Letinois (1)
    Olivier Duval (2)
    Laurent Martiny (1)
    Emmanuelle Charpentier (1)
    J茅r么me Devy (1)

    1. CNRS UMR7369 MEDyC, Laboratoire SiRMa, SFR CAP-Sant茅, Universit茅 de Reims Champagne-Ardenne, Moulin de la Housse, BP 1039, 51687, Reims cedex 2, France
    2. SONAS, UFR Sciences Pharmaceutiques et Ing茅nierie de la Sant茅, Universit茅 d鈥橝ngers, SFR QUASAV 4207, 16 bd Daviers, 49100, Angers, France
  • 刊物类别:Medicine
  • 刊物主题:Medicine & Public Health
    Oncology
    Pharmacology and Toxicology
  • 出版者:Springer Netherlands
  • ISSN:1573-0646
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