Glucocorticoid receptor genetic polymorphisms is associated with improvement of health-related quality of life in Chinese population with systemic lupus erythematosus

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• 作者：Yan-Feng Zou ; Jian-Hua Xu ; Fa-Ming Pan ; Jin-Hui Tao ; Sheng-Qian Xu…
• 关键词：Glucocorticoids ; Glucocorticoid receptor ; Health ; related quality of life ; Polymorphisms ; Systemic lupus erythematosus
• 刊名：Clinical Rheumatology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：34
• 期：9
• 页码：1537-1544
• 全文大小：318 KB
• 参考文献：1.D’Cruz DP, Khamashta MA, Hughes GR (2007) Systemic lupus erythematosus. Lancet 369:587-96CrossRef PubMed
  2.van Rossum EF, van den Akker EL (2011) Glucocorticoid resistance. Endocr Dev 20:127-36PubMed
  3.Zou YF, Xu JH, Wang F et al (2013) Association study of glucocorticoid receptor genetic polymorphisms with efficacy of glucocorticoids in systemic lupus erythematosus: a prospective cohort study. Autoimmunity 46:531-36CrossRef PubMed
  4.Zou YF, Xu JH, Tao JH et al (2013) Impact of environmental factors on efficacy of glucocorticoids in chinese population with systemic lupus erythematosus. Inflammation 36:1424-430CrossRef PubMed
  5.Adcock IM, Nasuhara Y, Stevens DA et al (1999) Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol 127:1003-011PubMed Central CrossRef PubMed
  6.Francke U, Foellmer BE (1989) The glucocorticoid receptor gene is in 5q31-q32 [corrected]. Genomics 4:610-12CrossRef PubMed
  7.Encío IJ, Detera-Wadleigh SD (1991) The genomic structure of the human glucocorticoid receptor. J Biol Chem 266:7182-188PubMed
  8.WHOQOL Group (1993) Study protocol for the World Health Organization project to develop a Quality of Life assessment instrument (WHOQOL). Qual Life Res 2:153-59CrossRef
  9.Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725CrossRef PubMed
  10.Newnham EA, Harwood KE, Page AC (2007) Evaluating the clinical significance of responses by psychiatric inpatients to the mental health subscales of the SF-36. J Affect Disord 98:91-7CrossRef PubMed
  11.Thumboo J, Strand V (2007) Health-related quality of life in patients with systemic lupus erythematosus: an update. Ann Acad Med Singap 36:115-22PubMed
  12.Galon J, Franchimont D, Hiroi N et al (2002) Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J 16:61-1CrossRef PubMed
  13.Mosca M, Tani C, Carli L et al (2011) Glucocorticoids in systemic lupus erythematosus. Clin Exp Rheumatol 29:S126–S129PubMed
  14.Nicolaides NC, Galata Z, Kino T et al (2010) The human glucocorticoid receptor: molecular basis of biologic function. Steroids 75:1-2PubMed Central CrossRef PubMed
  15.Manenschijn L, van den Akker EL, Lamberts SW et al (2009) Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci 1179:179-98CrossRef PubMed
  16.Dua AB, Touma Z, Toloza S et al (2013) Top 10 recent developments in health-related quality of life in patients with systemic lupus erythematosus. Curr Rheumatol Rep 15:380CrossRef PubMed
  17.Moldovan I, Katsaros E, Carr FN et al (2011) The Patient Reported Outcomes in Lupus (PATROL) study: role of depression in health-related quality of life in a Southern California lupus cohort. Lupus 20:1285-292CrossRef PubMed
  18.Anacker C, Zunszain PA, Carvalho LA et al (2011) The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology 36:415-25PubMed Central CrossRef PubMed
  19.Ga?ecka E, Szemraj J, Bieńkiewicz M et al (2013) Single nucleotide polymorphisms of NR3C1 gene and recurrent depressive disorder in population of Poland. Mol Biol Rep 40:1693-699PubMed Central CrossRef PubMed
  20.Hauer D, Weis F, Papassotiropoulos A et al (2011) Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy. Crit Care Med 39:643-50CrossRef PubMed
  21.Rostami S, Parsa-Yekta Z, Najafi-Ghezeljeh T et al (2015) Self-perception in Iranian adolescents with diabetes: a qualitative study. J Diabetes Metab Disord 14:36PubMed Central CrossRef PubMed
  22.Yang J, Lu YW, Pan HF et al (2012) Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors. Rheumatol Int 32:2393-399CrossRef PubMed
  23.Sun S, Chen J, Johannesson M et al (2011) Regional differences in health status in China: population health-related quality of life results from the National Health Services Survey 2008. Health Place 17:671-80CrossRef PubMed
  24.Costedoat-Chalumeau N, Amoura Z, Hulot JS et al (2007) Hydroxychloroquine in systemic lupus erythematosus. Lancet 369:1257-258CrossRef PubMed
  25.Petri M (2011) Use of hydroxychloroquine to prevent thrombosis in systemic lupus erythematosus and in antiphospholipid antibody-positive patients. Curr Rheumatol Rep 13:77-0CrossRef PubMed
  26.Carmichael SJ, Charles B, Tett SE (2003) Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis. Ther Drug Monit 25:671-81CrossRef PubMed
  
• 作者单位：Yan-Feng Zou (1)
  Jian-Hua Xu (2)
  Fa-Ming Pan (1)
  Jin-Hui Tao (3)
  Sheng-Qian Xu (2)
  Hui Xiao (2)
  Shuang Liu (2)
  Jing Cai (2)
  Li Lian (2)
  Pei-Ling Chen (2)
  De-Guang Wang (4)
  Sheng-Xiu Liu (5)
  Chun-Mei Liang (6)
  Qian-Ling Ye (7)
  Guo Tian (1)
  Min Wu (1)
  Yuan-Yuan Gu (1)
  Hai-Feng Pan (1)
  Hong Su (1)
  Dong-Qing Ye (1)
  
  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China
  2. Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China
  3. Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, 230001, Anhui, China
  4. Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China
  5. Institute of Dermatology and Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China
  6. Department of Laboratory Medicine, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
  7. Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  
• 出版者：Springer London
• ISSN：1434-9949

文摘

In our previous study, we found that glucocorticoid receptor (GR) gene genetic polymorphisms may play a major role in the efficacy of glucocorticoids (GCs) in Chinese systemic lupus erythematosus (SLE) patients. The aim of this study is to explore the association of GR gene genetic polymorphisms and improvement of health-related quality of life (HRQOL) in Chinese SLE patients treated with GCs. A total of 195 Chinese SLE patients were treated with GCs for 12 weeks. The HRQOL of patients was measured with the Medical Outcomes Study Short Form-36 (SF-36) at baseline and 12 weeks. Polymorphisms of GR gene were genotyped by using multiplex SNaPshot method. One hundred eighty-four patients (94.36 %) completed the 12-week follow-up. Twenty-three single-nucleotide polymorphisms of GR gene were genotyped. There was a significant association between rs10482672 polymorphism and improvement in physical function (P--.043), general health (P--.024), and social function (P--.013). The rs12656106 polymorphism was associated with improvement in the total score of SF-36 (P--.014), physical function (P--.013), general health (P--.010), vitality (P--.015), social function (P--.004), physical component summary (P--.016), and mental component summary (P--.014). The rs4912905 polymorphism was associated with improvement in bodily pain (P--.040) and general health (P--.038). The rs4912911 polymorphism was associated with improvement in general health (P--.026) and vitality (P--.027). The rs4986593 polymorphism was associated with improvement in bodily pain (P--.034). The rs7719514 polymorphism was associated with improvement in vitality (P--.002) and mental component summary (P--.041). We also found a significant association between rs9324924 polymorphism and improvement in physical function (P--.040), bodily pain (P--.007), and general health (P--.019). These results indicate that there may be an association of GR gene rs10482672, rs12656106, rs4912905, rs4912911, rs4986593, rs7719514, and rs9324924 polymorphisms with improvement of HRQOL in Chinese SLE patients treated with GCs. Keywords Glucocorticoids Glucocorticoid receptor Health-related quality of life Polymorphisms Systemic lupus erythematosus