Effects of environmentally relevant concentrations of metallic compounds on the flatfish Scophthalmus maximus: biomarkers of neurotoxicity, oxidative stress and metabolism

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• 作者：Bruno Nunes (1)
  Fátima Brand?o (1)
  Tania Sérgio (2)
  Sara Rodrigues (1) (2)
  Fernando Gon?alves (1)
  Alberto Teodorico Correia (2) (3)
  
• 关键词：Metals ; Cholinesterase impairment ; Oxidative stress ; Biomarker ; Antioxidant enzymes ; Turbot ; Ecological relevance
• 刊名：Environmental Science and Pollution Research
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：21
• 期：12
• 页码：7501-7511
• 全文大小：
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• 作者单位：Bruno Nunes (1)
  Fátima Brand?o (1)
  Tania Sérgio (2)
  Sara Rodrigues (1) (2)
  Fernando Gon?alves (1)
  Alberto Teodorico Correia (2) (3)
  
  1. Departamento de Biologia da Universidade de Aveiro, CESAM, Centro de Estudos do Ambiente e do Mar, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal
  2. CIIMAR/CIMAR, Centro Interdisciplinar de Investiga??o Marinha e Ambiental, Rua dos Bragas 289, Porto, 4050-123, Portugal
  3. FCS-UFP, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, Porto, 4200-150, Portugal
  
• ISSN：1614-7499

文摘

Flatfish species, such as the turbot (Scophthalmus maximus), are common targets for toxic effects, since they are exposed through the food chain (ingestion of contaminated preys) and are in direct contact with the waterborne contaminant and sediments. Furthermore, these fish species live in close proximity to interstitial water that frequently dissolves high amounts of contaminants, including metals. Despite this significant set of characteristics, the present knowledge concerning flatfish contamination and toxicity by metals is still scarce. To attain the objective of assessing the effects of metals on a flatfish species, S. maximus specimens were chronically exposed to lead, copper and zinc, at ecologically relevant concentrations, and biochemical (oxidative stress: catalase and glutathione S-transferases activities, and lipid peroxidation; neurotoxicity: cholinesterase activity) parameters were assessed on selected tissues (gills and liver). Copper had no significant effects on all tested parameters; lead was causative of significant increases in liver GSTs activities and also in lipoperoxidation of gill tissue; exposure to zinc caused a significant increase in catalase activity of gill tissue. None of the tested metals elicited noteworthy effects in terms of neurotoxicity. The obtained results showed that only the metal lead is of some environmental importance, since it was able to cause deleterious modifications of oxidative nature at relevant concentrations.