Chitosan nanoparticles as a potential drug delivery system attached to viscose cellulose fibers

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• 作者：Tijana Ristić ; Andrej Zabret ; Lidija Fras Zemljič ; Zdenka Peršin
• 关键词：Chitosan ; Water ; soluble N ; N ; N ; trimethyl chitosan derivative ; Cellulose viscose fibers ; Adsorption/desorption ; Drug delivery system
• 刊名：Cellulose
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：24
• 期：2
• 页码：739-753
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Bioorganic Chemistry; Physical Chemistry; Organic Chemistry; Polymer Sciences;
• 出版者：Springer Netherlands
• ISSN：1572-882X
• 卷排序：24

文摘

Chitosan and its water-soluble N,N,N-trimethyl derivative were attached to cellulose fibers in the form of nanoparticle dispersions. The attachment of the chitosan nanoparticles to the fiber surface was studied by evaluation of the quantity of chitosan amino groups using a conventional spectrophotometric method supported by X-ray photoelectron spectroscopy. The desorption kinetics of the chitosan nanoparticles from the fiber surface was also examined indirectly by the spectrophotometric method. Additionally, a model drug was incorporated into the optimal chitosan nanoparticles for subsequent attachment to fibers to create a potential fibrous drug delivery system aimed at gynecological use, i.e., tampons as antimicrobial agents themselves or as drug reservoirs.