High virulence sub-populations in Pseudomonas aeruginosa long-term cystic fibrosis airway infections

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• 作者：Siobhán O’Brien ; David Williams ; Joanne L. Fothergill ; Steve Paterson…
• 关键词：Pseudomonas aeruginosa ; Liverpool epidemic strain ; Public goods secretions ; Virulence ; Cystic fibrosis ; Pyoverdine ; Pyocyanin ; LasA protease
• 刊名：BMC Microbiology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：965KB
• 刊物主题：Microbiology; Biological Microscopy; Mycology; Parasitology; Virology; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-2180
• 卷排序：17

文摘

BackgroundPseudomonas aeruginosa typically displays loss of virulence-associated secretions over the course of chronic cystic fibrosis infections. This has led to the suggestion that virulence is a costly attribute in chronic infections. However, previous reports suggest that overproducing (OP) virulent pathotypes can coexist with non-producing mutants in the CF lung for many years. The consequences of such within-patient phenotypic diversity for the success of this pathogen are not fully understood. Here, we provide in-depth quantification of within-host variation in the production of three virulence associated secretions in the Liverpool cystic fibrosis epidemic strain of P. aeruginosa, and investgate the effect of this phenotypic variation on virulence in acute infections of an insect host model.