Effects of point spread function-based image reconstruction on neuroreceptor binding in positron emission tomography study with [11C]FLB 457

详细信息    查看全文

• 作者：Thonnapong Thongpraparn ; Yoko Ikoma…
• 关键词：PET ; Point spread function ; Image reconstruction ; Neuroreceptor ; [11C]FLB 457
• 刊名：Radiological Physics and Technology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：9
• 期：1
• 页码：127-137
• 全文大小：1,498 KB
• 参考文献：1.Lasnon C, Hicks RJ, Beauregard JM, Milner A, Paciencia M, Guizard AV, et al. Impact of point spread function reconstruction on thoracic lymph node staging with 18F-FDG PET/CT in non-small cell lung cancer. Clin Nucl Med. 2012;37:971–6.CrossRef PubMed
  2.Bellevre D, Fournier CB, Switsers O, Dugué AE, Levy C, Allouache D, et al. Staging the axilla in breast cancer patients with 18F-FDG PET: how small are the metastases that we can detect with new generation clinical PET systems? Eur J Nucl Med Mol Imaging. 2014;41:1103–12.PubMedCentral CrossRef PubMed
  3.Rapisarda E, Bettinardi V, Thielemans K, Gilardi MC. Image-based point spread function implementation in a fully 3D OSEM reconstruction algorithm for PET. Phys Med Biol. 2010;55:4131–51.CrossRef PubMed
  4.Panin VY, Kehren F, Michel C, Casey M. Fully 3-D PET reconstruction with system matrix derived from point source measurements. IEEE Trans Med Imag. 2006;25:907–21.CrossRef
  5.Tong S, Alessio AM, Kinahan PE. Noise and signal properties in PSF-based fully 3D PET image reconstruction: an experimental evaluation. Phys Med Biol. 2010;55:1453–73.PubMedCentral CrossRef PubMed
  6.Volkow ND, Fowler JS, Gatley SJ, Logan J, Wang GJ, Ding YS, et al. PET evaluation of the dopamine system of the human brain. J Nucl Med. 1996;37:1242–56.PubMed
  7.Wagner HN Jr, Burns HD, Dannals RF, Wong DF, Langstrom B, Duelfer T, et al. Imaging dopamine receptors in the human brain by positron tomography. Science. 1983;221:1264–6.CrossRef PubMed
  8.Wong DF, Gjedde A, Wagner HN Jr. Quantification of neuroreceptors in the living human brain. I. Irreversible binding of ligands. J Cereb Blood Flow Metab. 1986;6:137–46.CrossRef PubMed
  9.Farde L, Eriksson L, Blomquist G, Halldin C. Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET–a comparison to the equilibrium analysis. J Cereb Blood Flow Metab. 1989;9:696–708.CrossRef PubMed
  10.Varrone A, Sjöholm N, Eriksson L, Gulyás B, Halldin C, Farde L. Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT. Eur J Nucl Med Mol Imaging. 2009;36:1639–50.CrossRef PubMed
  11.Halldin C, Farde L, Hogberg T, Mohell N, Hall H, Suhara T, et al. Carbon-11-FLB 457: a radioligand for extrastriatal D2 dopamine receptors. J Nucl Med. 1995;36:1275–81.PubMed
  12.National Electrical Manufacturers Association. NEMA Standards Publication NU 2-2001: Performance Measurements of Positron Emission Tomographs. National Electrical Manufacturers Association. 2001.
  13.Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4:153–8.CrossRef PubMed
  14.Olsson H, Halldin C, Swahn CG, Farde L. Quantification of [11C] FLB 457 binding to extrastriatal dopamine receptors in the human brain. J Cereb Blood Flow Metab. 1999;19:1164–73.CrossRef PubMed
  15.Sureau FC, Reader AJ, Comtat C, Leroy C, Ribeiro MJ, Buvat I, et al. Impact of image-space resolution modeling for studies with the high-resolution research tomograph. J Nucl Med. 2008;49:1000–8.CrossRef PubMed
  16.Zeng GL. Gibbs artifact reduction by nonnegativity constraint. J Nucl Med Tech. 2011;39:213–9.CrossRef
  17.Nuyts J. Unconstrained image reconstruction with resolution modelling does not have a unique solution. EJNMMI Physics. 2014;1:98.CrossRef PubMed
  18.Nakamura A, Tanizaki Y, Takeuchi M, Ito S, Sano Y, Sato M, et al. Impact of point spread function correction in standardized uptake value quantification for positron emission tomography images: a study based on phantom experiments and clinical images. Nihon Hoshasen Gijyutsu Gakkai Zasshi. 2014;70:542–8.CrossRef
  19.Belanger MJ, Mann JJ, Parsey RV. OS-EM and FBP reconstructions at low count rates: effect on 3D PET studies of [11C] WAY-100635. Neuroimage. 2004;21:244–50.CrossRef PubMed
  20.Akamatsu G, Ishikawa K, Mitsumoto K, Taniguchi T, Ohya N, Baba S, et al. Improvement in PET/CT image quality with a combination of point-spread function and time-of-flight in relation to reconstruction parameters. J Nucl Med. 2012;53:1716–22.CrossRef PubMed
  
• 作者单位：Thonnapong Thongpraparn (1) (2)
  Yoko Ikoma (1)
  Takahiro Shiraishi (3)
  Taiga Yamaya (1)
  Hiroshi Ito (1)
  
  1. Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan
  2. Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkok-noi, Bangkok, 10700, Thailand
  3. Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan
  
• 刊物主题：Imaging / Radiology; Nuclear Medicine; Radiotherapy; Medical and Radiation Physics;
• 出版者：Springer Japan
• ISSN：1865-0341

文摘

The ordered subset expectation maximization with a point spread function (OSEM-PSF) was developed to improve the spatial resolution of reconstructed positron emission tomography (PET) images and has been reported to improve the contrast of hot spots in PET studies for oncology. However, in neuroreceptor imaging, the regional radioactivity concentration changes dynamically during the scan, and the effects of the PSF may differ among various radioligands or quantification methods. In this study, we investigated the effects of the PSF on quantification in PET studies with [11C]FLB 457 of dopamine D₂ receptors, using both phantom and human data acquired by the Siemens Biograph 16 imaging platform. In the phantom studies, we evaluated the hot contrast recovery coefficient (HCRC) for variously sized hot spheres and the linearity between the measured and true radioactivities in OSEM-PSF images. Next, in the human studies with [11C]FLB 457, radioactivity concentrations and binding potentials for the cerebral cortex and thalamus were compared between images reconstructed with and without PSF. In the phantom studies, the OSEM-PSF images showed a better HCRC compared to images without PSF, and they showed a good linear correlation with true radioactivity. In the human studies, the radioactivity concentration increased especially in small regions with high accumulation of [11C]FLB 457 when the PSF was included. However, little difference in the binding potentials was observed for the target regions between both types of reconstructed images. In conclusion, PSF-based reconstruction reduced the spill-over phenomena in small hot regions; however, it caused no increase in the binding potentials in the [11C]FLB 457 studies. Keywords PET Point spread function Image reconstruction Neuroreceptor [11C]FLB 457