Roles of alcohol drinking pattern in fatty liver in Japanese women

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• 作者：Akio Moriya (1)
  Yoshiaki Iwasaki (2) (3)
  Souhei Ohguchi (4)
  Eizo Kayashima (4)
  Tadahiko Mitsumune (4)
  Fusao Ikeda (3)
  Masaharu Ando (1)
  Kazuhide Yamamoto (3)
  
• 关键词：Nonalcoholic fatty liver disease ; Metabolic syndrome ; Alcohol consumption ; Drinking frequency ; Ultrasonography
• 刊名：Hepatology International
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：7
• 期：3
• 页码：859-868
• 全文大小：212KB
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• 作者单位：Akio Moriya (1)
  Yoshiaki Iwasaki (2) (3)
  Souhei Ohguchi (4)
  Eizo Kayashima (4)
  Tadahiko Mitsumune (4)
  Fusao Ikeda (3)
  Masaharu Ando (1)
  Kazuhide Yamamoto (3)
  
  1. Department of Medicine, Mitoyo General Hospital, 708 Himehama, Toyohama-cho, Kanonji, 769-1695, Japan
  2. Health Service Center, Okayama University, 2-1-1 Tsushima-Naka, Kita-ku, Okayama, 700-8530, Japan
  3. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
  4. Junpukai Health Maintenance Center, 2-3-1 Daiku, Kita-ku, Okayama, 700-0913, Japan
  

文摘

Purpose Several studies have reported an inverse association between moderate alcohol consumption and prevalence of fatty liver (FL) in men. We aimed to clarify this association in women. Methods We collected health checkup data from 4,921 Japanese women without concurrent liver disease (mean age 46.4?years) and performed a cross-sectional study to evaluate the influence of alcohol drinking patterns (frequency and amount) on the prevalence of FL as assessed by ultrasonography. Results Alcohol consumption was reported in 30.8?% of participants, and FL was observed in 13.8?% (15.5?% nondrinkers, 10.1?% drinkers). Alcohol consumption was inversely associated with FL prevalence [adjusted odds ratio (AOR) 0.79, 95?% confidence interval (CI) 0.63-.98]. In analyses stratified by drinking frequency and/or amount of alcohol consumed, the risk of FL decreased for the following categories: 0.1-9.9?g/drinking day (AOR 0.61, 95?% CI 0.44-.83) and 0.1-9.9?g/week (AOR 0.74, 95?% CI 0.55-.98). The amount of alcohol consumed directly correlated with the prevalence of FL in daily drinkers (p?<?0.05), whereas there was no correlation between the frequency of alcohol consumption and FL prevalence. Alanine aminotransferase levels were significantly lower for the following categories: 0.1-9.9?g/drinking day for 1-?days a week (p?=?0.016) and 0.1-9.9?g within 1- drinking days a week (p?=?0.004). Conclusions Minimal alcohol consumption appears to have protective effects against nonalcoholic FL disease in women, although an increase in the amount of alcohol consumed appears to nullify the protective effect.