A case of fulminant liver failure associated with hepatitis C virus

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• 作者：Hiromitsu Kanzaki (1)
  Akinobu Takaki (1)
  Takahito Yagi (2)
  Fusao Ikeda (1) (3)
  Tetsuya Yasunaka (1)
  Kazuko Koike (1)
  Yasuhiro Miyake (1)
  Yoshiaki Iwasaki (4)
  Kazuhiro Nouso (1) (3)
  Hiroshi Sadamori (2)
  Susumu Shinoura (2)
  Yuzo Umeda (2)
  Ryuichi Yoshida (2)
  Masashi Utusmi (2)
  Toshiyoshi Fujiwara (2)
  Kazuhide Yamamoto (1) (3)
  
• 关键词：Fulminant hepatitis ; HCV
• 刊名：Clinical Journal of Gastroenterology
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：7
• 期：2
• 页码：170-174
• 全文大小：468 KB
• 参考文献：1. Kato N. Molecular virology of hepatitis C virus. Acta Med Okayama. 2001;55:133-9.
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  7. Mochida S, Takikawa Y, Nakayama N, et al. Diagnostic criteria of acute liver failure: a report by the Intractable Hepato-Biliary Diseases Study Group of Japan. Hepatol Res. 2011;41:805-2. CrossRef
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• 作者单位：Hiromitsu Kanzaki (1)
  Akinobu Takaki (1)
  Takahito Yagi (2)
  Fusao Ikeda (1) (3)
  Tetsuya Yasunaka (1)
  Kazuko Koike (1)
  Yasuhiro Miyake (1)
  Yoshiaki Iwasaki (4)
  Kazuhiro Nouso (1) (3)
  Hiroshi Sadamori (2)
  Susumu Shinoura (2)
  Yuzo Umeda (2)
  Ryuichi Yoshida (2)
  Masashi Utusmi (2)
  Toshiyoshi Fujiwara (2)
  Kazuhide Yamamoto (1) (3)
  
  1. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
  2. Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  3. Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  4. Health Service Center, Okayama University, Okayama, Japan
  
• ISSN：1865-7265

文摘

Fulminant hepatitis due to acute hepatitis C virus (HCV) infection is rarely observed. We present a case study of a 21-year-old male patient who developed HCV-associated fulminant hepatitis after receiving steroid pulse therapy for optic neuritis. Despite daily plasmapheresis, the disease progressed to irreversible liver failure with grade 3 hepatic encephalopathy by the 6th day after symptom onset. The patient received a liver transplant on the 8th day. Serum anti-HCV antibody was negative at that time, but became positive on the 12th day. Positive HCV RNA in the serum at admission was reported after transplantation. Positive changes in anti-HCV antibodies and acute hepatitis with massive necrosis in the histology of the explanted liver indicated fulminant hepatitis due to acute HCV infection. Because of severe hepatitis recurrence, he started 12?months of interferon therapy on the 48th day, and obtained sustained virological response. His anti-HCV antibodies became negative again by 1.5?years after cessation of therapy. HCV genomes recovered from the patient’s serum on the 7th and 48th days revealed 2 different clones out of 20 clones with 30?% amino acid difference in hypervariable region 1 of HCV second envelope glycoprotein. One of the 2 clones expanded further after liver transplantation. We conclude that early diagnosis of HCV-associated fulminant hepatitis requires the detection of HCV RNA in the serum. Severe hepatitis recurrence after liver transplantation might occur in patients with fulminant hepatitis due to HCV because of its monoclonal expansion.