Gabarapl1 mediates androgen-regulated autophagy in prostate cancer

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• 作者：Chong-Wei Xie ; You Zhou ; Sheng-Lin Liu ; Zheng-Yu Fang ; Bing Su ; Wei Zhang
• 关键词：Gabarapl1 ; Autophagy ; Androgen ; Prostate cancer
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：36
• 期：11
• 页码：8727-8733
• 全文大小：1,844 KB
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• 作者单位：Chong-Wei Xie (1)
  You Zhou (1)
  Sheng-Lin Liu (1)
  Zheng-Yu Fang (1)
  Bing Su (2) (3)
  Wei Zhang (1)
  
  1. Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China
  2. Xinxiang Key Lab of Translational Cancer Research, The Third Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan, 453003, China
  3. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, The State University of New York, Buffalo, NY, 14214, USA
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Autophagy plays an important role in prostate cancer development. It promotes tumor cell survival and was found to be associated with androgen pathway. In the present study, we found that GABA(A) receptor-associated protein like 1 (Gabarapl1), a ubiquitin-like modifier, participates in the regulation of autophagy. Gabarapl1 is transcriptionally regulated by androgen receptor (AR) and has a repressive role in autophagy. Androgen deprivation downregulates Gabarapl1 in an AR dependent manner, resulting in the increase of autophagy flux. Elevated Gabarapl1 also represses the proliferation of prostate cancer cells. In summary, our study provides evidence to show that Gabarapl1 is a mediator involved in androgen-regulated autophagy process. Keywords Gabarapl1 Autophagy Androgen Prostate cancer