The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models
详细信息 查看全文
- 作者：Eric Hervouet ; Aurore Claude-Taupin ; Thierry Gauthier ; Valérie Perez…
- 关键词：Autophagy ; GABARAP ; GABARAPL1 ; GABARAPL2 ; Breast cancer ; CREB ; 1 ; DNA methylation ; Epigenetics
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,837 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was frequently downregulated in cancer cells while a high GABARAPL1 expression is a good prognosis marker for patients with lymph node-positive breast cancer.