Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models

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• 作者：Shaik Mohammad Naushad ; Sana Venkata Vijayalakshmi…
• 关键词：Serine hydroxymethyltransferase ; 5 ; Methyltetrahydrofolate ; homocysteine methyltransferase reductase ; Cytochrome P4501A1 ; Catechol ; o ; amine methyltransferase ; Reduced folate carrier1
• 刊名：Molecular Biology Reports
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：42
• 期：7
• 页码：1211-1224
• 全文大小：1,538 KB
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• 作者单位：Shaik Mohammad Naushad (1)
  Sana Venkata Vijayalakshmi (2)
  Yedluri Rupasree (2)
  Nadella Kumudini (3)
  Sampathkumar Sowganthika (1)
  Janardhanan Venketlakshmi Naidu (4)
  M. Janaki Ramaiah (1)
  Dunna Nageswara rao (1)
  Vijay Kumar Kutala (2)
  
  1. School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, 613401, India
  2. Department of Clinical Pharmacology & Therapeutics, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad, 500082, India
  3. Centre for Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, 500085, India
  4. Gastrocare Hospital, Trichy, 620018, India
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4978

文摘

Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene–gene interactions among these two metabolic pathways in four diseases i.e. breast cancer, systemic lupus erythematosus (SLE), coronary artery disease (CAD) and Parkinson’s disease (PD). Multifactor dimensionality reduction analysis was carried out on four case–control datasets. Cross-talk was observed between one-carbon and xenobiotic pathways in breast cancer (RFC 80 G>A, COMT H108L and TYMS 5-UTR 28?bp tandem repeat) and SLE (CYP1A1 m1, MTRR 66 A>G and GSTT1). Gene–gene interactions within one-carbon metabolic pathway were observed in CAD (GCPII 1561 C>T, SHMT 1420 C>T and MTHFR 677 C>T) and PD (cSHMT 1420 C>T, MTRR 66 A>G and RFC1 80 G>A). These interaction models showed good predictability of risk for PD (The area under the receiver operating characteristic curve (C)?=?0.83) and SLE (C?=?0.73); and moderate predictability of risk for breast cancer (C?=?0.64) and CAD (C?=?0.63). Cross-talk between one-carbon and xenobiotic pathways was observed in diseases with female preponderance. Gene–gene interactions within one-carbon metabolic pathway were observed in diseases with male preponderance.