The Emerging Role of “Liquid Biopsies,” Circulating Tumor Cells, and Circulating Cell-Free Tumor DNA in Lung Cancer Diagnosis and Identification of Resistance Mutations

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• 作者：Angela Esposito ; Carmen Criscitiello ; Dario Trapani…
• 关键词：Circulating tumor DNA ; Circulating tumor cell ; Liquid biopsy ; Intra ; tumor heterogeneity ; Disease monitoring ; Molecular resistance ; Early detection
• 刊名：Current Oncology Reports
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：
• 刊物主题：Oncology;
• 出版者：Springer US
• ISSN：1534-6269
• 卷排序：19

文摘

Therapeutic advances in the treatment of lung cancer are in part due to a more complete understanding of its genomic portrait. The serial monitoring of tumor genotypes, which are instable and prone to changes under selective pressure, is becoming increasingly needed. Although tumor biopsies remain the reference standard for the diagnosis and genotyping of lung cancer, they are invasive and not always feasible. The “liquid biopsies” have the potential to overcome many of these hurdles, allowing a rapid and accurate identification of de novo and resistant genetic alterations and a real-time monitoring of treatment responses. In this review, we provide insights into new liquid diagnostic platforms and discuss the role of circulating tumor cells and circulating tumor DNA in the diagnosis and identification of resistance mutations in lung cancer.