Loss of interleukin-21 leads to atrophic germinal centers in multicentric Castleman’s disease

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• 作者：Hidetaka Yajima ; Motohisa Yamamoto ; Yui Shimizu ; Nodoka Sakurai…
• 关键词：Bcl ; 6 ; Follicular helper T cell ; Germinal center ; Interleukin ; 21 ; Multicentric Castleman’s disease
• 刊名：Annals of Hematology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：95
• 期：1
• 页码：35-40
• 全文大小：1,188 KB
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• 作者单位：Hidetaka Yajima (1) (2)
  Motohisa Yamamoto (1)
  Yui Shimizu (1)
  Nodoka Sakurai (1) (3)
  Chisako Suzuki (1)
  Yasuyoshi Naishiro (1)
  Kohzoh Imai (4)
  Yasuhisa Shinomura (1) (5)
  Hiroki Takahashi (1)
  
  1. Division of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan
  2. Department of Internal Medicine and Gastroenterlogy, Sapporo Dohkohkai Hospital, Sapporo, Japan
  3. Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
  4. The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  5. Ikeda Municipal Hospital, Osaka, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Hematology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0584

文摘

Both multicentric Castleman’s disease (MCD) and immunoglobulin (Ig)G4-related disease (IgG4-RD) are systemic diseases, presenting with hypergammaglobulinemia and elevated serum levels of IgG4. However, with regard to histopathological findings, MCD shows atrophic germinal centers. On the other hand, expanded germinal centers are detected in IgG4-RD. We extracted germinal centers from specimens of each disorder by microdissection and analyzed the expression of mRNAs by real-time polymerase chain reaction to clarify the mechanisms underlying atrophied germinal centers in MCD. This analysis disclosed loss of interleukin (IL)-21 and B cell lymphoma (Bcl)-6 in the germinal centers of MCD. Loss of IL-21 is considered to be involved in the disappearance of Bcl-6 and leads to atrophied germinal centers in MCD. Keywords Bcl-6 Follicular helper T cell Germinal center Interleukin-21 Multicentric Castleman’s disease