Influence of polymorphisms of UDP-glycosyltransferases (UGT) 2B family genes UGT2B15, UGT2B17 and UGT2B28 on the development of prostate cancer in Korean men

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• 作者：Se-Ra Lee ; Myoung-Hyun Ahn ; Yung Hyun Choi ; Sun-Hee Leem
• 关键词：UGT2B family ; Glucuronidation ; Prostate cancer ; SNPs ; Insertion/deletion
• 刊名：Genes & Genomics
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：38
• 期：2
• 页码：225-233
• 全文大小：1,307 KB
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• 作者单位：Se-Ra Lee (1)
  Myoung-Hyun Ahn (1)
  Yung Hyun Choi (2)
  Sun-Hee Leem (1)
  
  1. Department of Biological Science, Dong-A University, Busan, 49315, Korea
  2. Department of Biochemistry, College of Oriental Medicine, Anti-Aging Research Center, Dongeui University, Busan, 614-052, Korea
  
• 刊物主题：Microbial Genetics and Genomics; Plant Genetics & Genomics; Animal Genetics and Genomics; Human Genetics;
• 出版者：Springer Netherlands
• ISSN：2092-9293

文摘

Prostate cancer is known as the fifth most common cancer in Korean male. The etiology of the prostate cancer remains unknown, but age, race, drug, family history, dietary habit and steroid hormone levels have been suggested as causative factors. Among these factors, variations in androgen hormone levels have been suggested as one of risk factors for the cancer. The glucuronidation is a major pathway of detoxification process of toxin and hormones within human body by UDP-glucuronosyltransferase (UGT) enzymes. Known as the androgen inactivating UGT2B enzyme family, UGT2B17 and UGT2B28 have common deletion region by copy number variation (CNV) and UGT2B15 has a single nucleotide polymorphism (SNP) (rs1902023: G > T) locus which contains the change from Asp to Tyr on exon 1. These polymorphisms were analyzed with genomic DNA extracted from 555 prostate cancer cases and 404 control males. There was no difference in the frequency of CNV and SNP of each UGT2B genes between prostate cancer cases and control males. In this study, we found the decreased risk (OR, 0.39; 95 % CI, 0.19–0.83; P = 0.011) of prostate cancer in individuals with UGT2B17 del/del type, UGT2B28 in/del type and UGT2B15 SNP TT type. Additionally, we found the length polymorphisms of the short tandem repeat (STR) in the allelic loci of UGT2B28 deletion regions and suggest that this locus can be used for a personal identification marker. Keywords UGT2B family Glucuronidation Prostate cancer SNPs Insertion/deletion