Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents

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• 作者：Johan Isaksson ; Elena L. Grigorenko…
• 关键词：DβH ; Conduct disorder ; Psychopathy ; Genetic
• 刊名：European Archives of Psychiatry and Clinical Neuroscience
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：266
• 期：8
• 页码：771-773
• 全文大小：377 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Psychiatry
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-8491
• 卷排序：266

文摘

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.