Antifungal Metabolites Produced by Chaetomium globosum No.04, an Endophytic Fungus Isolated from Ginkgo biloba

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• 作者：Guizhen Zhang (1)
  Yanhua Zhang (1)
  Jianchun Qin (1)
  Xiaoyan Qu (1)
  Jinliang Liu (1)
  Xiang Li (1)
  Hongyu Pan (1)
  
• 关键词：Chaetomium globosum ; Antifungal activity ; Chaetoglobosins
• 刊名：Indian Journal of Microbiology
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：53
• 期：2
• 页码：175-180
• 全文大小：373KB
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• 作者单位：Guizhen Zhang (1)
  Yanhua Zhang (1)
  Jianchun Qin (1)
  Xiaoyan Qu (1)
  Jinliang Liu (1)
  Xiang Li (1)
  Hongyu Pan (1)
  
  1. College of Plant Sciences, Changchun, Jilin, China
  
• ISSN：0973-7715

文摘

The fungal endophyte Chaetomium globosum No.04 was isolated from the medicinal plant Ginkgo biloba. The crude extract of the fungus fermentation were active in the agar-diffusion tests against the phytopathogenic fungi Rhizopus stolonifer and Coniothyrium diplodiella. Further bioassay-guided chemical investigation led to the isolation and purification of six alkaloids and three non-targeted compounds from 50?L fermentation of this endophytic fungus and their structures were elucidated as chaetoglobosin A, C, D, E, G, R (1-6), ergosterol, allantoin and uracil, by means of spectroscopic analysis. Compounds 1-6 showed significant growth inhibitory activity against R. stolonifer and C. diplodiella at a concentration of 20?μg/disc. We present here, for the first time, the potent antifungal activity of chaetoglobosins from endophytic fungi against two important phytopathogenic fungi R. stolonifer and C. diplodiella.