The zoonotic potential of avian influenza viruses isolated from wild waterfowl in Zambia

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• 作者：Edgar Simulundu (1) (2) (3)
  Naganori Nao (1)
  John Yabe (4)
  Nilton A. Muto (5)
  Thami Sithebe (3)
  Hirofumi Sawa (2) (5)
  Rashid Manzoor (1)
  Masahiro Kajihara (1)
  Mieko Muramatsu (1)
  Akihiro Ishii (1)
  Hirohito Ogawa (1)
  Aaron S. Mweene (2)
  Ayato Takada (1) (2)
  
• 刊名：Archives of Virology
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：159
• 期：10
• 页码：2633-2640
• 全文大小：1,175 KB
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• 作者单位：Edgar Simulundu (1) (2) (3)
  Naganori Nao (1)
  John Yabe (4)
  Nilton A. Muto (5)
  Thami Sithebe (3)
  Hirofumi Sawa (2) (5)
  Rashid Manzoor (1)
  Masahiro Kajihara (1)
  Mieko Muramatsu (1)
  Akihiro Ishii (1)
  Hirohito Ogawa (1)
  Aaron S. Mweene (2)
  Ayato Takada (1) (2)
  
  1. Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Kita-20, Nishi-10, Kita-ku, Sapporo, 001-0020, Japan
  2. Department of Disease Control, School of Veterinary Medicine, The University of Zambia, PO Box 32379, Lusaka, Zambia
  3. Department of Biological Sciences, Faculty of Agriculture Science and Technology, School of Environmental and Health Sciences, North West University, Mafikeng Campus, Private Bag X2046, Mmabatho, 2735, South Africa
  4. Department of Paraclinical Studies, School of Veterinary Medicine, The University of Zambia, PO Box 32379, Lusaka, Zambia
  5. Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Kita-20, Nishi-10, Kita-ku, Sapporo, 001-0020, Japan
  
• ISSN：1432-8798

文摘

Whilst remarkable progress in elucidating the mechanisms governing interspecies transmission and pathogenicity of highly pathogenic avian influenza viruses (AIVs) has been made, similar studies focusing on low-pathogenic AIVs isolated from the wild waterfowl reservoir are limited. We previously reported that two AIV strains (subtypes H6N2 and H3N8) isolated from wild waterfowl in Zambia harbored some amino acid residues preferentially associated with human influenza virus proteins (so-called human signatures) and replicated better in the lungs of infected mice and caused more morbidity than a strain lacking such residues. To further substantiate these observations, we infected chickens and mice intranasally with AIV strains of various subtypes (H3N6, H3N8, H4N6, H6N2, H9N1 and H11N9) isolated from wild waterfowl in Zambia. Although some strains induced seroconversion, all of the tested strains replicated poorly and were nonpathogenic for chickens. In contrast, most of the strains having human signatures replicated well in the lungs of mice, and one of these strains caused severe illness in mice and induced lung injury that was characterized by a severe accumulation of polymorphonuclear leukocytes. These results suggest that some strains tested in this study may have the potential to infect mammalian hosts directly without adaptation, which might possibly be associated with the possession of human signature residues. Close monitoring and evaluation of host-associated signatures may help to elucidate the prevalence and emergence of AIVs with potential for causing zoonotic infections.