The Relationship Between Acoustic Startle Response Measures and Cognitive Functions in Japanese Patients with Schizophrenia

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• 作者：Taro Kishi (1) (2) (3)
  Yasuhisa Fukuo (2)
  Tomo Okochi (2)
  Kunihiro Kawashima (2)
  Masatsugu Moriwaki (3)
  Osamu Furukawa (3)
  Kiyoshi Fujita (3) (4)
  Giovanna M. Musso (1)
  Christoph U. Correll (1)
  John M. Kane (1)
  Nakao Iwata (2)
  
• 关键词：Acoustic startle response ; Prepulse inhibition ; Habituation ; Cognitive function ; Attention ; Schizophrenia
• 刊名：NeuroMolecular Medicine
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：14
• 期：2
• 页码：131-138
• 全文大小：208KB
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• 作者单位：Taro Kishi (1) (2) (3)
  Yasuhisa Fukuo (2)
  Tomo Okochi (2)
  Kunihiro Kawashima (2)
  Masatsugu Moriwaki (3)
  Osamu Furukawa (3)
  Kiyoshi Fujita (3) (4)
  Giovanna M. Musso (1)
  Christoph U. Correll (1)
  John M. Kane (1)
  Nakao Iwata (2)
  
  1. Division of Psychiatry Research, The Zucker Hillside Hospital, 75-59 263rd Street, Glen Oaks, NY, 11004, USA
  2. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan
  3. Department of Psychiatry, The Okehazama Hospital, Toyoake, Aichi, 470-1168, Japan
  4. The Neuroscience Research Center, Toyoake, Aichi, 470-1168, Japan
  

文摘

Recently, schizophrenia endophenotypes have been actively investigated to better understand the pathophysiology of schizophrenia. Past studies have shown that cognitive functions, including working memory and executive function, correlate with acoustic startle responses, such as prepulse inhibition (PPI), in patients with schizophrenia. The aim of this study was to investigate the relationship between cognitive functions and acoustic startle response in Japanese patients with schizophrenia. In 100 patients with schizophrenia, we evaluated cognitive function, using the Brief Assessment of Cognition in Schizophrenia, Japanese-language version (BACS-J), and acoustic startle responses, including acoustic startle reflex, habituation, and PPI (three different intensities: 82, 86, and 90?dB SPL, equivalent to signal-to-noise ratios of +12, +16, and +20?dB, respectively). Using multiple regression analysis, we examined the relationship between acoustic startle responses and BACS-J primary measures or composite score. Level of attention was associated with magnitude of habituation in schizophrenia (P?=?0.0009, β?=??.357). None of the other domains of cognitive function were significantly associated with any measure of acoustic startle response. This included attention regarding ASR (P?=?0.513), PPI (P?=?0.521-.842), verbal memory (P?=?0.423-.981), working memory (P?=?0.312-.966), motor speed (P?=?0.323-.955), verbal fluency (P?=?0.125-.920), executive function (P?=?0.118-.470), and the BACS-J composite score (P?=?0.230-.912). In this first investigation of the relationship between cognitive functions and acoustic startle responses in Japanese patients with schizophrenia, attentional deficits correlated highly with the level of habituation. However, a replication study using other population samples is required to further investigate this relationship.