Cyr61 promotes growth of glioblastoma in vitro and in vivo

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• 作者：Gang Cheng ; Hangyu Zhang ; Leiming Zhang ; Jianning Zhang
• 关键词：Glioblastoma (GBM) ; Cyr61 ; PI3K ; Akt ; mTor
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：36
• 期：4
• 页码：2869-2873
• 全文大小：378 KB
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• 作者单位：Gang Cheng (1)
  Hangyu Zhang (2)
  Leiming Zhang (1)
  Jianning Zhang (1)
  
  1. Neurosurgery Institute, Navy General Hospital of PLA, Beijing, 100048, China
  2. Neurosurgery Institute, Chinese PLA General Hospital, Beijing, 100853, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

The molecular regulation of the growth of glioblastoma (GBM) is not completely understood. Here, we show that the Cyr61 levels were significantly higher in GBM than in the adjacent non-tumor tissues. Overexpression of Cyr61 enhanced the viability of GBM cells, while inhibition of Cyr61 decreased the viability of GBM cells, in vitro and in vivo. Further analyses revealed that Cyr61 seemed to activate PI3K/Akt/mTor signaling pathway to increase cell growth in GBM cells. Taken together, our findings suggest a potential role of Cyr61 in GBM growth and highlight Cyr61 as a novel target for GBM therapy.