Tularemia in Alaska, 1938 - 2010
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- 作者：Cristina M Hansen (1)
Amy J Vogler (2)
Paul Keim (2)
David M Wagner (2)
Karsten Hueffer (1) - 刊名：Acta Veterinaria Scandinavica
- 出版年：2011
- 出版时间：December 2011
- 年：2011
- 卷：53
- 期：1
- 全文大小：255KB
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Amy J Vogler (2)
Paul Keim (2)
David M Wagner (2)
Karsten Hueffer (1)
1. Institute of Arctic Biology and Department of Biology and Wildlife, University of Alaska Fairbanks, 902 N. Koyukuk Dr., Fairbanks, AK, 99775, USA
2. Center for Microbial Genetics and Genomics, Northern Arizona University, PO Box 4073, Flagstaff, AZ, 86011, USA
文摘
Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick (Haemophysalis leporis-palustris) in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from < 1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats (VNTR) analysis (MLVA) system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state.