Comparison of neutrophil–lymphocyte ratio (NLR) in Parkinson’s disease subtypes

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• 作者：Ceyla Ataç Uçar ; Burcu Gökçe Çokal ; Hanzade Aybüke Ünal Artık&#8230
• 关键词：Idiopathic Parkinson’s disease ; Inflammation ; Parkinson’s disease subtypes ; Neurodegeneration
• 刊名：Neurological Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：2
• 页码：287-293
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Neurology; Neuroradiology; Neurosurgery; Psychiatry;
• 出版者：Springer Milan
• ISSN：1590-3478
• 卷排序：38

文摘

It has been hypothesized that chronic inflammation may play an important role in the development and progression of the neurodegeneration of Idiopathic Parkinson’s disease (IPD). Neutrophil–lymphocyte ratio (NLR) is a marker that indicates the peripheral inflammation. There is only one study regarding NLR and IPD. In this study, we assessed to investigate NLR in patients with IPD, comparing the results with controls and to determine whether there is a difference in NLR levels in subgroups of IPD (akinetic-rigid and tremor-dominant) differ in their levels of NLR. Medical records of 200 IPD patients and 60 controls reviewed retrospectively. Forty-six IPD patients met the inclusion criteria. NLR was calculated by dividing neutrophil count to lymphocyte count. Thirteen akinetic-rigid (AR-IPD) and thirty-three tremor-dominant (TD-IPD) patients’ and controls results were compared. There was not a statistically difference between the NLR levels of IPD patients, controls, and AR-IPD and TD-IPD patients. This result suggests that cerebral inflammation is in the forefront in the development of neurodegeneration in IPD, and that more evidence is needed for the role of peripheral inflammation in the development progression of disease.