Primary adenocarcinoma of the urinary bladder: a single site analysis of 21 cases

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• 作者：Hu Zhang (1)
  Haowen Jiang (1)
  Zhong Wu (1)
  Zujun Fang (1)
  Jie Fan (1)
  Qiang Ding (1)
  
• 关键词：Bladder cancer ; Survival ; Recurrence ; Urachus ; Adenocarcinoma
• 刊名：International Urology and Nephrology
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：45
• 期：1
• 页码：107-111
• 全文大小：217KB
• 参考文献：1. Nielsen K, Nielsen KK (1983) Adenocarcinoma in exstrophy of the bladder-the last case in Scandinavia? A case report and review of the literature. J Urol 130:1180-182
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• 作者单位：Hu Zhang (1)
  Haowen Jiang (1)
  Zhong Wu (1)
  Zujun Fang (1)
  Jie Fan (1)
  Qiang Ding (1)
  
  1. Department of Urology, Huashan Hospital, Fudan University, No. 12, WuLuMuQi Middle Road, Shanghai, China
  
• ISSN：1573-2584

文摘

Purpose To investigate whether there is a difference between urachal and non-urachal adenocarcinomas in terms of patient survival and to determine the significant prognostic factors. Methods Thirty-four patients with histologically proven adenocarcinoma of the urinary bladder were treated at Huashan hospital between 1999 and 2010. 13 cases were excluded, including 12 patients with metastatic involvement from gastrointestinal or reproductive tracts and one without follow-up data after the initial consultation. Life tables, Kaplan–Meier, Cox regression analysis and log-rank test were used. Results The difference between patients with urachal adenocarcinoma and patients with non-urachal adenocarcinoma was not statistically significant using the Kaplan–Meier estimates (P?=?0.0763). Clinical stage had a significant influence on survival (P?=?0.0320, Fig.?2). Patients with surgical resection including partial and radical cystectomy did not have a better prognosis (P?=?0.7992, Fig.?3). However, the difference is statistically significant between patients who received partial cystectomy and patients who received radical cystectomy (P?=?0.0123, Fig.?4). Conclusion Survival of Patients with adenocarcinoma is correlated with clinical stage. Patients with urachal adenocarcinoma and non-urachal adenocarcinoma may have similar survival outcome. Tumor stage was a highly significant predictor of outcome (P?=?0.0320). Surgical resection seems to be more important than chemotherapy in the cases of adenocarcinoma of the urinary bladder. We are in favor of radical cystectomy for all patients.