MicroRNA-663 induction upon oxidative stress in cultured human fibroblasts depends on the chronological age of the donor
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- 作者：Mari?tte E. C. Waaijer (1)
Matthias Wieser (2) (3)
Regina Grillari-Voglauer (2) (3) (4)
Diana van Heemst (1) (5)
Johannes Grillari (4) (7)
Andrea B. Maier (6) (8) - 关键词：MicroRNA ; 663 ; Chronological age ; Biological age ; Senescence ; Oxidative stress ; Human dermal fibroblasts
- 刊名：Biogerontology
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：15
- 期：3
- 页码：269-278
- 全文大小：
- 参考文献：1. Afonyushkin T, Oskolkova OV, Bochkov VN (2012) Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids. Atherosclerosis. 225(1):50-5 CrossRef
2. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479:232-36 CrossRef
3. Bootsma-van der Wiel A, Gussekloo J, de Craen AJ, Van EE, Bloem BR, Westendorp RG (2002) Common chronic diseases and general impairments as determinants of walking disability in the oldest-old population. J Am Geriatr Soc 50:1405-410 CrossRef
4. Borgan E, Navon R, Vollan HK, Schlichting E, Sauer T, Yakhini Z, Lingjaerde OC, Sorlie T, Borresen-Dale AL (2011) Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue. Mol Oncol 5:564-76 CrossRef
5. Buratti E, De CL, Stuani C, Romano M, Baralle M, Baralle F (2010) Nuclear factor TDP-43 can affect selected microRNA levels. FEBS J 277:2268-281 CrossRef
6. Chen LH, Chiou GY, Chen YW, Li HY, Chiou SH (2010) MicroRNA and aging: a novel modulator in regulating the aging network. Ageing Res Rev 9(Suppl 1):S59–S66 CrossRef
7. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-59 CrossRef
8. Dekker P, Maier AB, van Heemst D, de Koning-Treurniet C, Blom J, Dirks RW, Tanke HJ, Westendorp RG (2009) Stress-induced responses of human skin fibroblasts in vitro reflect human longevity. Aging Cell 8:595-03 CrossRef
9. Dekker P, de Lange MJ, Dirks RW, van Heemst D, Tanke HJ, Westendorp RG, Maier AB (2011) Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro. J Gerontol A Biol Sci Med Sci 66:45-0 CrossRef
10. Dekker P, van Baalen LM, Dirks RW, Slagboom PE, van Heemst D, Tanke HJ, Westendorp RG, Maier AB (2012) Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age. J Gerontol A Biol Sci Med Sci 67:456-64 CrossRef
11. Ghildiyal M, Zamore PD (2009) Small silencing RNAs: an expanding universe. Nat Rev Genet 10:94-08 CrossRef
12. Goncalves AP, Maximo V, Lima J, Singh KK, Soares P, Videira A (2011) Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. Biochim Biophys Acta 1813:492-99 CrossRef
13. Grillari J, Grillari-Voglauer R (2010) Novel modulators of senescence, aging, and longevity: small non-coding RNAs enter the stage. Exp Gerontol 45:302-11 CrossRef
14. Hackl M et al (2010) miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell 9:291-96 CrossRef
15. Lardizabal MN, Nocito AL, Daniele SM, Ornella LA, Palatnik JF, Veggi LM (2012) Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity. PLoS ONE 7:e36323 CrossRef
16. Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA, Robinson JP (2003) Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem 278:8516-525 CrossRef
17. Liang P, Lv C, Jiang B, Long X, Zhang P, Zhang M, Xie T, Huang X (2012) MicroRNA profiling in denatured dermis of deep burn patients. Burns 38:534-40 CrossRef
18. Liu ZY, Zhang GL, Wang MM, Xiong YN, Cui HQ (2011) MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation. Asian Pac J Cancer Prev 12:2819-823
19. Maes OC, Sarojini H, Wang E (2009) Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts. J Cell Physiol 221:109-19 CrossRef
20. Maier AB, le Cessie S, de Koning-Treurniet C, Blom J, Westendorp RG, van Heemst D (2007) Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians. Aging Cell 6:27-3 CrossRef
21. Marasa BS, Srikantan S, Martindale JL, Kim MM, Lee EK, Gorospe M, Abdelmohsen K (2010) MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany. NY) 2:333-43
22. Marques FZ, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang YH, Charchar FJ, Morris BJ (2011) Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs. Hypertension 58:1093-098 CrossRef
23. Ni CW, Qiu H, Jo H (2011) MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells. Am J Physiol Heart Circ Physiol 300:H1762–H1769 CrossRef
24. Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z, Ran Y (2010) Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells. Oncol Rep 24:105-12
25. Pizzimenti S, Ferracin M, Sabbioni S, Toaldo C, Pettazzoni P, Dianzani MU, Negrini M, Barrera G (2009) “MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. Free Radic Biol Med 46:282-88 CrossRef
26. Schoenmaker M, de Craen AJ, de Meijer PH, Beekman M, Blauw GJ, Slagboom PE, Westendorp RG (2006) Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet 14:79-4
27. Sharbati-Tehrani S, Kutz-Lohroff B, Bergbauer R, Scholven J, Einspanier R (2008) miR-Q: a novel quantitative RT-PCR approach for the expression profiling of small RNA molecules such as miRNAs in a complex sample. BMC Mol Biol 9:34 CrossRef
28. Son DJ et al (2013) The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nat Commun 4:3000 CrossRef
29. Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (2010) Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD. Carcinogenesis 31:1561-566 CrossRef
30. Waaijer ME, Parish WE, Strongitharm BH, van Heemst D, Slagboom PE, de Craen AJ, Sedivy JM, Westendorp RG, Gunn DA, Maier AB (2012) The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell 11:722-25 CrossRef
31. Westendorp RG, van Heemst D, Rozing MP, Frolich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE (2009) Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: the Leiden Longevity Study. J Am Geriatr Soc 57:1634-637 CrossRef
32. Wijsman CA, Rozing MP, Streefland TC, le Cessie S, Mooijaart SP, Slagboom PE, Westendorp RG, Pijl H, van Heemst D (2011) Familial longevity is marked by enhanced insulin sensitivity. Aging Cell 10:114-21 CrossRef
33. Yi C et al (2012) MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. Oncogene 11:4421-433 CrossRef - 作者单位：Mari?tte E. C. Waaijer (1)
Matthias Wieser (2) (3)
Regina Grillari-Voglauer (2) (3) (4)
Diana van Heemst (1) (5)
Johannes Grillari (4) (7)
Andrea B. Maier (6) (8)
1. Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
2. Department of Biotechnology, BOKU-VIBT University of Natural Resources and Applied Life Sciences Vienna, Austria, Muthgasse 18, A-1190, Vienna, Austria
3. ACIB–Austrian Center of Industrial Biotechnology, Vienna, Austria
4. Evercyte GmbH, Vienna, Austria
5. Netherlands Consortium for Healthy Aging, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
7. Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of Biotechnology, BOKU-VIBT University of Natural Resources and Applied Life Sciences Vienna, Austria, Muthgasse 18, A-1190, Vienna, Austria
6. Department of Internal Medicine, Section of Gerontology and Geriatrics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
8. Amsterdam Center on Aging, 1007 MB, Postbus 7057, Amsterdam, The Netherlands - ISSN：1573-6768
文摘
MicroRNAs, regulators of messenger RNA translation, have been observed to influence many physiological processes, amongst them the process of aging. Higher levels of microRNA-663 (miR-663) have previously been observed in human dermal fibroblasts subject to both replicative and stress-induced senescence compared to early passage cells. Also, higher levels of miR-663 have been found in memory T-cells and in human fibroblasts derived from older donors compared to younger donors. In previous studies we observed that dermal fibroblasts from donors of different chronological and biological age respond differentially to oxidative stress measured by markers of cellular senescence and apoptosis. In the present study we set out to study the association between miR-663 levels and chronological and biological age. Therefore we tested in a total of 92 human dermal fibroblast strains whether the levels of miR-663 in non-stressed and stressed conditions (fibroblasts were treated with 0.6?μM rotenone in stressed conditions) were different in young, middle aged and old donors and whether they were different in middle aged donors dependent on their biological age, as indicated by the propensity for familial longevity. In non-stressed conditions the level of miR-663 did not differ between donors of different age categories and was not dependent on biological age. Levels of miR-663 did not differ dependent on biological age in stressed conditions either. However, for different age categories the level of miR-663 in stressed conditions did differ: the level of miR-663 was higher at higher age categories. Also, the ratio of miR-663 induction upon stress was significantly higher in donors from older age categories. In conclusion, we present evidence for an association of miR-663 upon stress and chronological age.