Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation
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- 作者：Takuma Kitanishi ; Hiroshi T. Ito ; Yuichiro Hayashi…
- 关键词：Hippocampus ; Place cells ; Navigation ; Oscillations ; Left–right asymmetry ; Synaptic plasticity
- 刊名：The Journal of Physiological Sciences
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：67
- 期：2
- 页码：247-258
- 全文大小：
- 刊物主题：Human Physiology; Neurosciences; Animal Biochemistry; Animal Physiology; Cell Physiology; Neurobiology;
- 出版者：Springer Japan
- ISSN：1880-6562
- 卷排序：67
文摘
The hippocampus and associated structures are responsible for episodic memory in humans. In rodents, the most prominent behavioral correlate of hippocampal neural activity is place coding, which is thought to underlie spatial navigation. While episodic memory is considered to be unique to humans in a restricted context, it has been proposed that the same neural circuitry and algorithms that enable spatial coding and navigation also support episodic memory. Here we review the recent progress in neural circuit mechanisms of hippocampal activity by introducing several topics: (1) cooperation and specialization of the bilateral hippocampi, (2) the role of synaptic plasticity in gamma phase-locking of spikes and place cell formation, (3) impaired goal-related activity and oscillations in a mouse model of mental disorders, and (4) a prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation.