Understanding the cholesterol metabolism-perturbing effects of docosahexaenoic acid by gas chromatography–mass spectrometry targeted metabonomic profiling

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• 作者：Priti Bahety ; Thi Hai Van Nguyen ; Yanjun Hong ; Luqi Zhang…
• 关键词：Docosahexaenoic acid (DHA) ; Amyloid β ; precursor protein (AβPP) ; Cholesterol ; Gas chromatography ; Metabonomics ; HMG ; CoA reductase ; Squalene epoxidase
• 刊名：European Journal of Nutrition
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：56
• 期：1
• 页码：29-43
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nutrition;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1293
• 卷排序：56

文摘

PurposeOver the past few decades, docosahexaenoic acid (DHA) has gained special attention for management of cholesterol-associated metabolic disorders and neurodegenerative diseases such as Alzheimer’s disease (AD) owing to its neuroprotective, anti-inflammatory and hypolipidemic properties. Several epidemiological studies have reported the effect of DHA in reducing the risk of developing AD by lowering cholesterol. Hypercholesterolemia is a pro-amyloidogenic factor influencing the enzymatic processing of amyloid-β precursor protein (AβPP) to toxic β-amyloid. However, the mechanism by which DHA modulates the cholesterol pathway has not been established. Thus, the objective of this study was to investigate the mechanism of regulation of cholesterol metabolism by DHA in an AβPP₆₉₅ overexpressing AD cell model.