Mitochondrial KATP Channels Control Glioma Radioresistance by Regulating ROS-Induced ERK Activation

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• 作者：Lianyan Huang ; Boxing Li ; Shihao Tang ; Hongbo Guo ; Wenjun Li…
• 关键词：Mitochondrial KATP channel ; Glioma ; Radioresistance ; Reactive oxygen species production ; ERK activation
• 刊名：Molecular Neurobiology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：52
• 期：1
• 页码：626-637
• 全文大小：3,418 KB
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• 作者单位：Lianyan Huang (1)
  Boxing Li (2)
  Shihao Tang (1)
  Hongbo Guo (3)
  Wenjun Li (1)
  Xiaozhou Huang (5)
  Wenjuan Yan (4)
  Fei Zou (1)
  
  1. Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, Guangdong, China
  2. Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
  3. Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
  5. The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
  4. Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Malignant glioma is the most prevalent form of malignant brain tumor. Although radiotherapy is widely used in glioma treatment, the radioresistance of glioma cells limits the success of the glioma treatment. The lack of effective targets and signaling pathways to reverse glioma radioresistance is the critical obstacle in successful treatment. In this study, we demonstrate that mitochondrial ATP-sensitive potassium channels (mtKATP channels) are overexpressed in glioma cells and are closely related to the malignancy grade and the overall survival of the patients. Importantly, we showed that mtKATP channels could control glioma radioresistance by regulating reactive oxygen species (ROS)-induced ERK activation. The inhibition of mtKATP channels suppresses glioma radioresistance by inhibiting ERK activation both in vitro and in vivo. These findings reveal the important roles of the mitochondria and mtKATP channels as key regulators in the radioresistance of glioma cells, and suggest that mtKATP channel blockers and MAPK/ERK kinase (MEK) inhibitors are potential targets for drug development of glioma treatments.