Bone marrow metastasis in primary bronchial mucoepidermoid carcinoma: a case report

详细信息    查看全文

• 作者：Zhenyu Pan (1)
  Guozi Yang (1)
  Limei Qu (2)
  Tingting Yuan (3)
  Zhonghua Du (4)
  Lihua Dong (1)
  
  1. Department of Radiotherapy ; Norman Bethune First Hospital ; Jilin University ; 71 Xinmin Street ; Changchun ; 130021 ; China
  2. Department of Pathology ; Norman Bethune First Hospital ; Jilin University ; 71 Xinmin Street ; Changchun ; 130021 ; China
  3. Department of Radiology ; Norman Bethune First Hospital ; Jilin University ; 71 Xinmin Street ; Changchun ; 130021 ; China
  4. Cancer Center ; Norman Bethune First Hospital ; Jilin University ; 71 Xinmin Street ; Changchun ; 130021 ; China
  
• 关键词：Mucoepidermoid carcinoma ; Lung ; Bone marrow metastasis
• 刊名：World Journal of Surgical Oncology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：361 KB
• 参考文献：1. Leonardi, HK, Jung-Legg, Y, Legg, MA, Neptune, WB (1978) Tracheobronchial mucoepidermoid carcinoma. J Thorac Cardiovasc Surg 76: pp. 431-438
  2. Yousem, S, Nicholson, A Mucoepidermoid carcinoma. In: Travis, W, Brambilla, E, Muller-Hermlink, H, Harris, C eds. (2004) World Health Organization classification of tumours.Pathology and genetics of tumours of the lung, pleura, thymus and heart. IARC, Lyon, pp. 63-64
  3. Liu, X, Adams, AL (2007) Mucoepidermoid carcinoma of the bronchus: a review. Arch Pathol Lab Med 131: pp. 1400-1404
  4. Hashemzade, S, Taghizadieh, A, Rashidi, F, Esmaeili, HA, Mohammadreza, G (2011) Mucoepidermoid carcinoma of trachea in a 22聽years old woman: a case report. Pneumologia 60: pp. 164-165
  5. Yousem, SA, Hochholzer, L (1987) Mucoepidermoid tumors of the lung. Cancer 60: pp. 1346-1352 CrossRef
  6. Shimizu, J, Watanabe, Y, Oda, M, Morita, K, Tsunezuka, Y, Nonomura, A (1998) Clinicopathologic study of mucoepidermoid carcinoma of the lung. Int Surg 83: pp. 1-3
  7. Li, X, Zhang, W, Wu, X, Sun, C, Chen, M, Zeng, Q (2012) Mucoepidermoid carcinoma of the lung: common findings and unusual appearances on CT. Clin Imaging 36: pp. 8-13 CrossRef
  8. Xiao, L, Luxi, S, Ying, T, Yizhi, L, Lingyun, W, Quan, P (2009) Diagnosis of unknown nonhematological tumors by bone marrow biopsy: a retrospective analysis of 10,112 samples. J Cancer Res Clin Oncol 135: pp. 687-693 CrossRef
  9. Ozkan, M, Er, O, Karahan, IO, Deniz, K, Co艧kun, R, K眉莽眉k, C, Yurci, A, Altinba艧, M (2007) Rectal carcinoid tumor with bone marrow and osteoblastic bone metastasis: a case report. Turk J Gastroenterol 18: pp. 111-114
  10. Krishnan, C, George, TI, Arber, DA (2007) Bone marrow metastases: a survey of nonhematologic metastases with immunohistochemical study of metastatic carcinomas. Appl Immunohistochem Mol Morphol 15: pp. 1-7 CrossRef
  
• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819

文摘

Primary bronchial mucoepidermoid carcinoma in the lung is relatively rare. It rarely presents with the highly malignant biological characteristic of bone marrow metastasis. We describe a case of this disease with bone marrow metastasis. A 56-year-old man with the primary manifestation of bone pain and bloodstained sputum had two abnormal shadows on the left inferior lobar bronchus and peripheral tissue of the lower lobe of the left lung, respectively. Computed tomography-guided percutaneous puncture biopsy and bone imaging confirmed the diagnosis of high-grade bronchial mucoepidermoid carcinoma with bone metastasis. However, the patient soon presented with progressive hemoglobin and platelet decline and severe multi-organ hemorrhage. Subsequently, we performed bone marrow aspiration and biopsy, which revealed malignant cells and necrosis. The patient deteriorated rapidly from the disease, and died on the 16th day of admission. We hope that this case report will increase awareness of the possibility of primary high-grade bronchial mucoepidermoid carcinoma metastasizing to the bone marrow, which might be a poor prognostic factor.