Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation

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• 作者：Judith Stift (1)
  Hideo A. Baba (2)
  Elisabeth Huber (3)
  Birgit Federmann (4)
  Hans-Peter Fischer (5)
  Annette Schmitt-Graeff (6)
  Herrad Baurmann (7)
  Wolfgang Bethge (8)
  Peter Schirmacher (9)
  Fritz Wrba (1)
  Hildegard Greinix (10)
  Falko Fend (4)
  Rainer Schwerdtfeger (7)
  Howard M. Shulman (11)
  Daniel Wolff (12)
  Thomas Longerich (9)
  
• 关键词：Liver ; GvHD ; Biopsy ; Consensus
• 刊名：Virchows Archiv
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：464
• 期：2
• 页码：175-190
• 全文大小：809 KB
• 作者单位：Judith Stift (1)
  Hideo A. Baba (2)
  Elisabeth Huber (3)
  Birgit Federmann (4)
  Hans-Peter Fischer (5)
  Annette Schmitt-Graeff (6)
  Herrad Baurmann (7)
  Wolfgang Bethge (8)
  Peter Schirmacher (9)
  Fritz Wrba (1)
  Hildegard Greinix (10)
  Falko Fend (4)
  Rainer Schwerdtfeger (7)
  Howard M. Shulman (11)
  Daniel Wolff (12)
  Thomas Longerich (9)
  
  1. Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria
  2. Department of Pathology and Neuropathology, Essen University Hospital, Essen, Germany
  3. Institute of Pathology, University of Regensburg, Regensburg, Germany
  4. Institute of Pathology, University of Tübingen, Tübingen, Germany
  5. Institute of Pathology, University of Bonn, Bonn, Germany
  6. Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany
  7. German Clinic for Diagnostic, BMT Unit, Wiesbaden, Germany
  8. Department of Medicine, University Hospital Tübingen, Tübingen, Germany
  9. Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
  10. Department of Internal Medicine I, Bone Marrow Transplantation, Medical University of Vienna, Vienna, Austria
  11. Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA, USA
  12. Department of Internal Medicine III, University of Regensburg, Regensburg, Germany
  
• ISSN：1432-2307

文摘

After allogeneic hematopoietic cell transplantation (alloHCT) liver biopsy is performed for enigmatic liver disorders when noninvasive diagnostic steps have failed in establishing a definitive diagnosis. This document provides an updated consensus on the prerequisites for proper evaluation of liver biopsies in alloHCT patients and the histological diagnostic criteria for liver graft-versus-host disease (GvHD). The Working Group’s recommendations for the histological diagnosis of liver GvHD were derived from the peer-reviewed literature and from the consensus diagnosis of a total of 30 coded liver biopsies. Acceptance of the recommendations was tested by a survey distributed to all HCT centers in Austria, Germany and Switzerland. Consensus was achieved for biopsy indications, methods of sample acquisition and processing, reporting and interpretation of biopsy findings. As GvHD is variably treated and the treatment modalities have changed over time, the panel endorses the use of more frequent biopsies in clinical studies in order to improve the present challenging clinical and diagnostic situation.