Variations in association of Interleukin 6 -G174C single nucleotide polymorphism with type 2 diabetes mellitus—a review

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• 作者：Amina Nadeem (1)
  Abdul Khaliq Naveed (2)
  Muhammad Mazhar Hussain (1)
  Muhammad Aslam (3)
  Arif Siddiqui (4)
  Sheikh Abdul Saeed (5)
  
• 关键词：Interleukin ; 6 ; Diabetes mellitus ; Single nucleotide polymorphism
• 刊名：International Journal of Diabetes in Developing Countries
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：33
• 期：4
• 页码：186-191
• 全文大小：154 KB
• 作者单位：Amina Nadeem (1)
  Abdul Khaliq Naveed (2)
  Muhammad Mazhar Hussain (1)
  Muhammad Aslam (3)
  Arif Siddiqui (4)
  Sheikh Abdul Saeed (5)
  
  1. Dept of Physiology, Army Medical College, National University of Sciences and Technology, Islamabad, Pakistan
  2. Dept of Biochemistry, Army Medical College, National University of Sciences and Technology, Islamabad, Pakistan
  3. Vice Chancellor, University of Health Sciences, Lahore, Pakistan
  4. Dept of Physiology, Islamic International Medical College, Rifah University, Rawalpindi, Pakistan
  5. Dept of Physiology, King Saud Bin Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
  
• ISSN：1998-3832

文摘

Inflammation plays a role in the etiology of type 2 diabetes mellitus (DM). Interleukin-6 is one of the inflammatory markers which play role in the pathogenesis of diabetes mellitus DM. Single nucleotide polymorphism (SNP); -G174C in interleukin ? (IL-6) gene promoter area has been reported to be associated with type 2 DM (T2DM). The frequency of polymorphism is found to be variable in various ethnic groups and also within an ethnic group. Many studies reported a positive association between T2DM and IL-6 SNP although quite a number of other studies failed to find such association. IL-6 polymorphism has been found to be associated with higher serum IL-6 levels, insulin resistance and BMI, although these findings are also challenged by many studies. There is no single explanation for such highly variable results in different studies. Presence of yet unidentified gene polymorphism in linkage disequilibrium with IL-6 SNP could be responsible. The different results can also be attributed to the study groups differing as age, gender distribution, age of onset of disease, life style, degree of obesity and glucose tolerance. This review highlights the varying results reported in association of IL 6 –G174C SNP with risk of T2DM, serum IL-6 levels, BMI and insulin resistance.