Sarcoma-like tumor originating from oligodendroglioma

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• 作者：Takuhiro Shoji ; Ryuta Saito ; Masayuki Kanamori ; Yukihiko Sonoda…
• 关键词：Oligodendroglioma ; Sarcoma ; Fluorescent in situ hybridization ; 1p/19q co ; deletion ; Isocitrate dehydrogenase ; 1
• 刊名：Brain Tumor Pathology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：33
• 期：4
• 页码：255-260
• 全文大小：1,744 KB
• 刊物主题：Neurosurgery; Neurology; Pathology; Oncology; Cancer Research;
• 出版者：Springer Japan
• ISSN：1861-387X
• 卷排序：33

文摘

We present a case of sarcoma occurring at a site of resected oligodendroglioma without preceding radiotherapy or chemotherapy. Oligosarcoma occurring at sites of resected oligodendroglioma or anaplastic oligodendroglioma with sarcomatous components are rare. Although meningioma or sarcoma-like lesions are sometimes reported after glioma-targeted radiotherapy, those without preceding radiotherapy are quite rare. Moreover, cases of sarcoma without oligodendroglial components occurring at a site of resected oligodendroglioma have never been reported. In this case, fluorescent in situ hybridization analysis revealed 1p/19q co-deletion in both the first tumor and second tumors. Additionally, immunohistochemistry revealed mutated isocitrate dehydrogenase 1 in both tumors. Taken together, these findings suggest a monoclonal tumor origin. Consequently, this case may indicate a new mechanism of development of sarcomatous lesions occurring at the site of a resected glioma.