MR-Guided Delivery of Hydrophilic Molecular Imaging Agents Across the Blood-Brain Barrier Through Focused Ultrasound

详细信息    查看全文

• 作者：Raag D. Airan ; Catherine A. Foss ; Nicholas P. K. Ellens…
• 关键词：Key wordsMRgFUS ; Blood ; brain barrier ; GCPII ; PSMA ; NIRF
• 刊名：Molecular Imaging and Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 页码：24-30
• 全文大小：
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：19

文摘

PurposeA wide variety of hydrophilic imaging and therapeutic agents are unable to gain access to the central nervous system (CNS) due to the blood-brain barrier (BBB). In particular, unless a particular transporter exists that may transport the agent across the BBB, most agents that are larger than 500 Da or that are hydrophilic will be excluded by the BBB. Glutamate carboxypeptidase II (GCPII), also known as the prostate-specific membrane antigen (PSMA) in the periphery, has been implicated in various neuropsychiatric conditions. As all agents that target GCPII are hydrophilic and thereby excluded from the CNS, we used GCPII as a platform for demonstrating our MR-guided focused ultrasound (MRgFUS) technique for delivery of GCPII/PSMA-specific imaging agents to the brain.