The Role of Phagocytes and NETs in Dermatophytosis

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• 作者：Fábio Seiti Yamada Yoshikawa ; Sandro Rogério De Almeida
• 关键词：Dermatophytosis ; Phagocytes ; Macrophages ; Dendritic cells ; Neutrophils ; Innate immunity
• 刊名：Mycopathologia
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：182
• 期：1-2
• 页码：263-272
• 全文大小：410KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Microbiology; Medical Microbiology; Eukaryotic Microbiology; Microbial Ecology; Plant Sciences;
• 出版者：Springer Netherlands
• ISSN：1573-0832
• 卷排序：182

文摘

Innate immunity is the host first line of defense against pathogens. However, only in recent years, we are beginning to better understand the ways it operates. A key player is this branch of the immune response that are the phagocytes, as macrophages, dendritic cells and neutrophils. These cells act as sentinels, employing specialized receptors in the sensing of invaders and host injury, and readily responding to them by production of inflammatory mediators. They afford protection not only by ingesting and destroying pathogens, but also by providing a suitable biochemical environment that shapes the adaptive response. In this review, we aim to present a broad perspective about the role of phagocytes in dermatophytosis, focusing on the mechanisms possibly involved in protective and non-protective responses. A full understanding of how phagocytes fit in the pathogenesis of these infections may open the venue for the development of new and more effective therapeutic approaches.