Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes
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- 作者：Shouguo Gao ; Nathaniel Wolanyk ; Ye Chen ; Shuang Jia…
- 关键词：Co ; expression network ; Network structure ; Transcription regulation ; Entropy ; Type 1 diabetes
- 刊名：BMC Medical Genomics
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：900KB
- 刊物主题：Human Genetics; Microarrays; Gene Expression;
- 出版者：BioMed Central
- ISSN：1755-8794
- 卷排序：10
文摘
BackgroundType 1 diabetes (T1D) is an autoimmune disease and extensive evidence has indicated a critical role of both the innate and the adaptive arms of immune system in disease development. To date most clinical trials of immunomodulation therapies failed to show efficacy. A number of gene expression studies of T1D have been carried out. However, a systems analysis of the expression variations of the innate and adaptive immunity gene sets, or their co-expression network structures in cohorts at different disease states or of different disease risks, is not available till now.