Differential lncRNA expression profiles in brown and white adipose tissues

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• 作者：Jiantao Chen (1) (2)
  Xianwei Cui (1)
  Chunmei Shi (1)
  Ling Chen (1)
  Lei Yang (1)
  Lingxia Pang (1)
  Jun Zhang (1)
  Xirong Guo (1)
  Jiaqin Wang (2)
  Chenbo Ji (1)
  
  1. Nanjing Maternity and Child Health Care Institute ; Nanjing Maternity and Child Health Care Hospital Affiliated with Nanjing Medical University ; Nanjing ; 210029 ; China
  2. Department of Pediatrics ; The Third Affiliated Hospital of Xinxiang Medical University ; Xinxiang ; 453003 ; China
  
• 关键词：Brown adipose tissue ; White adipose tissue ; Long non ; coding RNA ; Adipogenesis
• 刊名：Molecular Genetics and Genomics
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：290
• 期：2
• 页码：699-707
• 全文大小：1,712 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biochemistry
  Microbial Genetics and Genomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1617-4623

文摘

Long non-coding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. It can serve as key co-activators of proteins involved in transcriptional regulation. Studies have found that white and brown adipocytes both originate from the mesoderm. However, it remains unclear whether lncRNAs function during adipogenesis or in energy metabolism in brown adipose tissue (BAT) and white adipose tissue (WAT). In this study, we used lncRNA microarray technology to evaluate differences in the lncRNA expression profiles of WAT and BAT. We observed 735 up-regulated and 877 down-regulated lncRNAs (fold change >4.0). To reveal the potential functions of these lncRNAs, we applied GO and pathway analyses to study the differentially expressed lncRNAs. We found that AK142386 and AK133540 may affect adipogenesis and metabolism. Our data indicate that AK142386 and AK133540 may be involved in BAT and WAT development through their target genes Hoxa3 and Acad10. Together, we have identified numerous lncRNAs and these lncRNAs can potentially serve as a required component for proper adipogenesis.