Gastro-intestinal stromal tumor (GIST) complicating a colonic interposition: a novel case report

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• 作者：Maaz B Badshah ; Haris Riaz ; Mark A Korsten ; Atiya Dhala…
• 刊名：BMC Research Notes
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：7
• 期：1
• 全文大小：2,058 KB
• 参考文献：1. Miettinen, M, Lasota, J (2006) Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 23: pp. 70-83 CrossRef
  2. Levy, AD, Remotti, HE, Thompson, WM, Sobin, LH, Miettinen, M (2003) Gastrointestinal stromal tumors: radiologic features with pathologic correlation. Radiographics 23: pp. 283-304 CrossRef
  3. Chirica, M, De Chaisemartin, C, Munoz-Bongrand, N, Halimi, B, Celerier, M, Cattan, P, Sarfati, E (2009) [Colonic interposition for esophageal replacement after caustic ingestion]. J Chir (Paris) 146: pp. 240-249 CrossRef
  4. Han, Y, Cheng, QS, Li, XF, Wang, XP (2004) Surgical management of esophageal strictures after caustic burns: A 30 years of experience. World J Gastroenterol 10: pp. 2846-2849
  5. Bando, H, Ikematsu, H, Fu, KI, Oono, Y, Kojima, T, Minashi, K, Yano, T, Matsuda, T, Saito, Y, Kaneko, K, Ohtsu, A (2010) A laterally-spreading tumor in a colonic interposition treated by endoscopic submucosal dissection. World J Gastroenterol 16: pp. 392-394 CrossRef
  6. Zhou, L, Liu, C, Bai, JG, Wei, JC, Qu, K, Tian, F, Tai, MH, Wang, RT, Meng, FD (2012) A rare giant gastrointestinal stromal tumor (GIST) of the stomach traversing the upper abdomen: a case report and literature review. World J Surg Oncol 10: pp. 66 CrossRef
  7. Miettinen, M, Sarlomo-Rikala, M, Sobin, LH, Lasota, J (2000) Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases. Am J Surg Pathol 24: pp. 1339-1352 CrossRef
  8. Fletcher, CDM, Berman, JJ, Corless, C, Gorstein, F, Lasota, J, Longley, BJ, Miettinen, M, O’Leary, TJ, Remotti, H, Rubin, BP, Shmookler, B, Sobin, LH, Weiss, SW (2002) Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 33: pp. 459-465 CrossRef
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1756-0500

文摘

Background Gastrointestinal stromal tumor (GIST) is a rare tumor comprising 0.1-0.3% of all gastrointestinal (GI) malignancies. Stomach followed by small intestine is the most common sites of involvement, implicated in 95% of the cases. We present a case of GIST complicating a colonic interposition. To the best of the author's knowledge, this is the first reported case of GIST complicating a colonic interposition. Case presentation A 47 year old African American male presented to the emergency department with intermittent, severe chest pain. Past medical history was significant for alkali (NaOH) ingestion during 1980 for which esophageal resection and a colonic pull-through was performed. A CXR revealed a widened mediastinum and CT scan chest revealed showed a large (11.4 × 8.3 × 12.1 cm) vascular mediastinal mass. At endoscopy, a large, ulcerated, cratered and friable mass was found at 29cm extending to 36cm at which point the lower anastomosis of the colonic pull through was present. Multiple endoscopic biopsies were obtained which showed that the tumor was immunoreactive with CD117, CD34 and DOG1 while markers of carcinoma, melanoma and lymphoma were negative. In light of the pathology report, the immunohistochemistry and the CT scans, the tumor was classified as a stage 4 GIST of colonic interposition. Conclusions GIST can complicate unusual locations such as colonic interposition and should be kept in the differential diagnosis of such unusual presentations.