Safety and Effectiveness of Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator in 80?Years and Older Acute Ischemic Stroke Patients

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• 作者：Yan Chen ; Chen-hua Li ; Yu-Xin Wang ; Chen-Hao Zhang…
• 关键词：Elderly ; 80?years ; Acute ischemic stroke ; Intravenous thrombolysis ; Recombinant tissue plasminogen activator
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：72
• 期：3
• 页码：883-888
• 全文大小：343 KB
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• 作者单位：Yan Chen (1)
  Chen-hua Li (1)
  Yu-Xin Wang (1)
  Chen-Hao Zhang (1)
  Zhong Dong (1)
  Fang-fang Zhang (1)
  Jin-Huan Wang (1)
  Pei-Lan Zhang (1)
  
  1. Department of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, 300060, China
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

This study aims to explore the safety and efficacy of intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) in elderly (?0?years old) acute ischemic stroke (AIS) patients. The clinical data of patients who were treated in Tianjin Huanhu Hospital from June 2012 to November 2013 were retrospectively analyzed; among them, 404 patients had received IVT with rt-PA and 200 patients had not received IVT. Among ?0-year-old patients, 204 had received IVT and 200 had not. And the 404 patients who had received IVT were divided into two subgroups: elderly (?0?years of age; n?=?204) and controls (<80?years old; n?=?200). The incidence of intracranial hemorrhage (ICH) and symptomatic intracranial hemorrhage, case fatality rate, and other prognostic indicators were compared. Among all ?0-year-old patients, the IVT subgroup had significantly superior good outcome rates than the non-IVT subgroup at 24-h and 3-month along with significantly lower case fatality rate. But for the patients those who had received IVT, the incidence of ICH and the 7-day case fatality rate were not significantly increased in both the elderly and control subgroups. The 24-h and 3-month good outcome rates were not significantly different between these two subgroups as well. IVT with rt-PA is a safe and effective treatment for ?0-year-old AIS patients.