Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

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• 作者：Shui-xing Zhang (1)
  Qian-jun Jia (1)
  Zhong-ping Zhang (2)
  Chang-hong Liang (1)
  Wen-bo Chen (1)
  Qian-hui Qiu (1)
  He Li (1)
  
• 关键词：Intravoxel incoherent motion ; MRI ; Nasopharyngeal carcinoma ; DWI ; Enlarged adenoids
• 刊名：European Radiology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：24
• 期：8
• 页码：1998-2004
• 全文大小：909 KB
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• 作者单位：Shui-xing Zhang (1)
  Qian-jun Jia (1)
  Zhong-ping Zhang (2)
  Chang-hong Liang (1)
  Wen-bo Chen (1)
  Qian-hui Qiu (1)
  He Li (1)
  
  1. Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, 510080, Guangzhou, Guangdong Prov., People’s Republic of China
  2. Applied Science Lab, GE Healthcare, GE Tower 10/F, Huacheng Ave. 87, Tianhe District, 510623, Guangzhou, Guangdong Prov., People’s Republic of China
  
• ISSN：1432-1084

文摘

Objectives We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). Methods Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0-00?s/mm2). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids. Results IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P--.001) and f (P--.0001) were significantly lower in patients with NPC than in patients with enlarged adenoids, whereas D* was significantly higher (P--.0001). However, the ADC was not significantly different between the two groups (P--.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P--.05). Conclusions IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC. Key Points -Intravoxel incoherent motion (IVIM) analysis permits separate quantification of diffusion and perfusion. -IVIM DWI is a feasible technique for investigating primary NPC. -IVIM suggests that primary NPC tissue voxels exhibit both perfusion and diffusion.