Erfahrungen aus 15聽Jahren Investigator-initiierten klinischen Studien zur axialen Spondyloarthritis
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- 作者：Prof. Dr. J. Sieper (1)
J. Braun (2)
1. Med. Klinik I ; Rheumatologie ; Charit茅 Universit盲tsmedizin Berlin ; Campus Benjamin Franklin ; Hindenburgdamm 30 ; 12200 ; Berlin ; Deutschland
2. Rheumazentrum Ruhrgebiet ; Herne ; Deutschland - 关键词：Therapie ; Diagnostik ; Epidemiologie ; Klinische Forschung ; Rheumatologie ; Therapy ; Diagnostics ; Epidemiology ; Clinical research ; Rheumatology
- 刊名：Zeitschrift f篓鹿r Rheumatologie
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：74
- 期：2
- 页码：125-131
- 全文大小：606 KB
- 参考文献：1. Baraliakos, (2013) Arthritis Res Ther 15: pp. R67 nal" href="http://dx.doi.org/10.1186/ar4244" target="_blank" title="It opens in new window">CrossRef
2. Baraliakos, (2014) Ann Rheum Dis 73: pp. 710 nal" href="http://dx.doi.org/10.1136/annrheumdis-2012-202698" target="_blank" title="It opens in new window">CrossRef
3. Baraliakos, (2014) Ann Rheum Dis 73: pp. 1819 nal" href="http://dx.doi.org/10.1136/annrheumdis-2013-203425" target="_blank" title="It opens in new window">CrossRef
4. Baraliakos X, Listing J, Fritz C et al (2011) Persistent clinical efficacy and safety of infliximab in ankylosing spondylitis after 8 years 鈥?early clinical response predicts long-term outcome. Rheumatology (Oxford) 50:1690鈥?699
5. Brandt, (2000) Arthritis Rheum 43: pp. 1346 nal" href="http://dx.doi.org/10.1002/1529-0131(200006)43:6<1346::AID-ANR18>3.0.CO;2-E" target="_blank" title="It opens in new window">CrossRef
6. Brandt, (2002) J Rheumatol 29: pp. 118
7. Brandt, (2003) Arthritis Rheum 48: pp. 1667 nal" href="http://dx.doi.org/10.1002/art.11017" target="_blank" title="It opens in new window">CrossRef
8. Brandt, (2004) Ann Rheum Dis 63: pp. 1438 nal" href="http://dx.doi.org/10.1136/ard.2003.016717" target="_blank" title="It opens in new window">CrossRef
9. Braun A, Gnann H, Saracbasi E et al (2013) Optimizing the identification of patients with axial spondyloarthritis in primary care 鈥?the case for a two-step strategy combining the most relevant clinical items with HLA B27. Rheumatology (Oxford) 52:1418鈥?424
10. Braun, (2011) Ann Rheum Dis 70: pp. 1782 nal" href="http://dx.doi.org/10.1136/ard.2011.151167" target="_blank" title="It opens in new window">CrossRef
11. Braun, (1994) Arthritis Rheum 37: pp. 1039 nal" href="http://dx.doi.org/10.1002/art.1780370709" target="_blank" title="It opens in new window">CrossRef
12. Braun, (1995) Arthritis Rheum 38: pp. 499 nal" href="http://dx.doi.org/10.1002/art.1780380407" target="_blank" title="It opens in new window">CrossRef
13. Braun, (1998) Arthritis Rheum 41: pp. 58 nal" href="http://dx.doi.org/10.1002/1529-0131(199801)41:1<58::AID-ART8>3.0.CO;2-G" target="_blank" title="It opens in new window">CrossRef
14. Braun, (1998) Rheum Dis Clin North Am 24: pp. 697 nal" href="http://dx.doi.org/10.1016/S0889-857X(05)70038-7" target="_blank" title="It opens in new window">CrossRef
15. Braun, (2002) Lancet 359: pp. 1187 nal" href="http://dx.doi.org/10.1016/S0140-6736(02)08215-6" target="_blank" title="It opens in new window">CrossRef
16. Braun, (2006) Ann Rheum Dis 65: pp. 1147 nal" href="http://dx.doi.org/10.1136/ard.2006.052878" target="_blank" title="It opens in new window">CrossRef
17. Haibel, (2007) Ann Rheum Dis 66: pp. 419 nal" href="http://dx.doi.org/10.1136/ard.2006.054098" target="_blank" title="It opens in new window">CrossRef
18. Haibel, (2008) Arthritis Rheum 58: pp. 1981 nal" href="http://dx.doi.org/10.1002/art.23606" target="_blank" title="It opens in new window">CrossRef
19. Haibel, (2005) Ann Rheum Dis 64: pp. 296 nal" href="http://dx.doi.org/10.1136/ard.2004.023176" target="_blank" title="It opens in new window">CrossRef
20. Machein U, Buss B, Spiller I et al (2002) Effective treatment of early rheumatoid arthritis with a combination of methotrexate, prednisolone and cyclosporin. Rheumatology (Oxford) 41:110鈥?11
21. Poddubnyy, (2014) Ann Rheum Dis 73: pp. 817 nal" href="http://dx.doi.org/10.1136/annrheumdis-2013-204248" target="_blank" title="It opens in new window">CrossRef
22. Poddubnyy, (2011) Ann Rheum Dis 70: pp. 1369 nal" href="http://dx.doi.org/10.1136/ard.2010.145995" target="_blank" title="It opens in new window">CrossRef
23. Rudwaleit, (2009) Arthritis Rheum 60: pp. 717 nal" href="http://dx.doi.org/10.1002/art.24483" target="_blank" title="It opens in new window">CrossRef
24. Rudwaleit, (2009) Ann Rheum Dis 68: pp. 777 nal" href="http://dx.doi.org/10.1136/ard.2009.108233" target="_blank" title="It opens in new window">CrossRef
25. Sieper, (1999) Arthritis Rheum 42: pp. 1386 nal" href="http://dx.doi.org/10.1002/1529-0131(199907)42:7<1386::AID-ANR12>3.0.CO;2-E" target="_blank" title="It opens in new window">CrossRef
26. Sieper, (1996) Arthritis Rheum 39: pp. 41 nal" href="http://dx.doi.org/10.1002/art.1780390106" target="_blank" title="It opens in new window">CrossRef
27. Sieper, (2005) Ann Rheum Dis 64: pp. 659 nal" href="http://dx.doi.org/10.1136/ard.2004.028753" target="_blank" title="It opens in new window">CrossRef
28. Song, (2011) Ann Rheum Dis 70: pp. 1108 nal" href="http://dx.doi.org/10.1136/ard.2010.145946" target="_blank" title="It opens in new window">CrossRef
29. Song, (2010) Arthritis Rheum 62: pp. 1290 nal" href="http://dx.doi.org/10.1002/art.27383" target="_blank" title="It opens in new window">CrossRef
30. Song, (2011) Ann Rheum Dis 70: pp. 590 nal" href="http://dx.doi.org/10.1136/ard.2010.139667" target="_blank" title="It opens in new window">CrossRef
31. Brandt, (2011) Arthritis Rheum 44: pp. 2936 nal" href="http://dx.doi.org/10.1002/1529-0131(200112)44:12<2936::AID-ART483>3.0.CO;2-M" target="_blank" title="It opens in new window">CrossRef
32. Kiltz, (2012) Arthritis Care Res: pp. 1415 nal" href="http://dx.doi.org/10.1002/acr.21688" target="_blank" title="It opens in new window">CrossRef - 刊物主题：Internal Medicine; Rheumatology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1435-1250
文摘
Background Clinical research is receiving an increasing amount of attention and is essential for improving treatment of patients with rheumatic diseases. Aims This article reports on 15 years of experience with conducting investigator-initiated studies on axial spondyloarthritis including ankylosing spondylitis. Results We have organized and successfully conducted a series of open-labelled and placebo-controlled double-blind treatment studies and also non-interventional studies on this topic. The installation of a qualified and motivated trial unit and intensive collaboration with a statistician were crucial requirements for success. These results have increased our knowledge about the disease and changed and improved the diagnostic possibilities and the therapeutic options. Conclusion Investigator-initiated trials are an important link between basic and clinical research and can substantially contribute to improvement of patient care. This kind of research should be more systematically funded in the future.