Green synthesis and biological evaluation of some new benzothiazolo [2,3-b] quinazolin-1-ones as anticancer agents

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• 作者：Jaiprakash N. Sangshetti ; Deepak K. Lokwani…
• 关键词：Aminobenzthiazole ; Cyclic diketones ; Water ; mediated reaction ; Benzothiazoloquinazolinones ; Anticancer activity ; Docking study
• 刊名：Medicinal Chemistry Research
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：23
• 期：11
• 页码：4893-4900
• 全文大小：798 KB
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• 作者单位：Jaiprakash N. Sangshetti (1)
  Deepak K. Lokwani (2)
  Rashmi S. Chouthe (1)
  Ashok Ganure (3)
  Bhuvan Raval (4)
  Firoz A. Kalam Khan (1)
  Devanand B. Shinde (2)
  
  1. Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, 431 001, MS, India
  2. Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 31004, MS, India
  3. Sahyadri College of Pharmacy, Methwade, Sholapur, MS, India
  4. K. J. College of Pharmacy, Vadasma, Gujarat, India
  
• ISSN：1554-8120

文摘

The simple, multicomponent, water-mediated synthesis of benzothiazolo [2,3-b] quinazolin-1-ones were carried out from aminobenzthiazoles, cyclic β diketone, and aromatic aldehydes. The simplicity, easy work up, short reaction time, and use of environmentally benign water as a solvent are some advantages of this proposed method. The newly synthesized compounds were evaluated for cytotoxicity against a panel of human cancer cell lines (U-937, Hep-2, vero, and MCF-7). Among the synthesized compounds, the compounds 4a and 4d showed higher anticancer activity. The result of DNA fragmentation analysis showed that the compound 4d induced dose-dependent apoptosis. This preliminary study encouraged us to consider the compounds 4a and 4d as interesting leads for further optimization.