Development of NIR-II fluorescence image-guided and pH-responsive nanocapsules for cocktail drug delivery

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• 作者：Sheng Huang ; Shan Peng ; Yuanbao Li ; Jiabin Cui ; Hongli Chen ; Leyu Wang
• 关键词：near IR fluorescence ; pH responsive ; cocktail drug delivery
• 刊名：Nano Research
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：8
• 期：6
• 页码：1932-1943
• 全文大小：1,770 KB
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• 作者单位：Sheng Huang (1)
  Shan Peng (1)
  Yuanbao Li (1)
  Jiabin Cui (1)
  Hongli Chen (1)
  Leyu Wang (1)
  
  1. State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, 100029, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chinese Library of Science
  Chemistry
  Nanotechnology
  
• 出版者：Tsinghua University Press, co-published with Springer-Verlag GmbH
• ISSN：1998-0000

文摘

Nanocapsule-based targeted delivery and stimulus-responsive release can increase drug effectiveness, while reducing the side effects of the drug. However, difficulties in the scale-up synthesis, fast burst release, and low degradability, could hamper the translation of drug nanocapsules from lab to clinic. Here we have controllably functionalized the biodegradable and widely available polysuccinimide, in order to obtain an amphiphilic poly(amino acid). Using this polymer, we designed nanocapsules (< 100 nm) for hydrophobic drug delivery, which could facilitate tumor targeting, hydrogen bond-based pH-responsive release, and real-time fluorescence tracking, in the second near-infrared region. This method is versatile, eco-friendly, and easy to scale up at low costs. In addition, this system can carry a cocktail of drugs, obtained by loading multiple anticancer drugs to the same vehicle. Our nanocapsules were observed to be stable in blood vessels (pH = 7.4), and the pH-responsive release (pH = 5.0 in lysosome) was sustained. The chemotherapy results in tumor-xenografted mice suggested that our nanocapsule was safe and efficient, and may be a useful tool for drug delivery.