Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

详细信息    查看全文

• 作者：Jianying Jing BS (1)
  Dan Wang BS (2)
  Yi Jiao MS (3)
  Xiaofeng Wang PhD (2)
  Hao Wen PhD (4)
  Renyong Lin PhD (4)
  Jianzhong Jin MS (2)
  Li Jin PhD (2)
  
• 关键词：Uygur ; hypertension ; G protein ; polymorphism
• 刊名：Frontiers of Medicine
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：1
• 期：2
• 页码：230-233
• 全文大小：130KB
• 参考文献：1. PRC National Blood Pressure Survey Cooperative Group: Prevalence and Development Trends of Hypertensionin China. Chin J Hypertens, 1995, 3(Suppl): 7 (in Chinese)
  2. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma A M, Ritz E, Wichmann H E, Jakobs K H, Horsthemke B. Association of a haman G-protein beta 3 subunit variant with hypertension. Nat Genet, 1998, 18(1): 45-8 CrossRef
  3. Beige J, Hohenbleicher H, Distler A, Sharma AM. G protein beta 3 subunit C825T variant and ambulatory blood pressure in essential hypertension. Hypertension, 1999, 33(4): 1049-051
  4. Hegele R A, Harris S B, Hanley A J, Cao H, Zinman B. G-protein / β3-subunit gene variant and blood pressure variation in Canadian Oji-Cree. Hypertension, 1998, 32(4): 688-92
  5. Benjafield AV, Jeyasingam C L, Nyholt D R, Griffiths L R, Morris B J. G-protein / β3 Subunit gene (GNB3) Variant in Causation of essential Hypertension. Hypertension, 1998, 32(6): 1094-097
  6. Larson N, Hutchinson R, Boerwinkle E. Lack of Association of 3 Functional gene Variants With Hypertension in African Americans. Hypertension, 2000, 35(6): 1297-300
  7. Kato N, Sugiyama T, Morita H, Kurihara H, Yamori Y, Yazaki Y. G protein beta 3 subunit variant and essential hypertension in Japanese. Hypertension, 1998, 32(5): 935-38
  8. Zhang M H, Liu G S, Shi Y, Shi J, Chen Y, Liu W L, Luo L M, Wang L, Yi J. G-Rrotein / β3 Subunit Gene Polyism and Essential Hypertension. Chin J Hypertens, 2001, 9(4): 288-91 (in Chinese)
  9. Dai S P, Shi J P, Ding Q, Wang H L, Dong L Y, Sun D, Fang K, Zhao Y, Dai Y. Polymorphism Analysis of 825C/T of the G-protein / β3 Subunit in High Risk Population of Hypertension in the Northeast China. Acta Genetica Sinica, 2002, 29(4): 294-98 (in Chinese)
  10. Siffert W, Forster P, Jockel K H, Mvere D A, Brinkmann B, Naber C, Crookes R, Du P Heyns A, Epplen J T, Fridey J, Freedman B I, Muller N, Stolke D, Sharma A M, Al Moutaery K, Grosse-Wilde H, Buerbaum B, Ehrlich T, Ahmad H R, Horsthemke B, Du Toit E D, Tiilikainen A, Ge J, Wang Y, Rosskopf D. Worldwide ethnic distribution of the G protein beta 3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol, 1999, 10(9): 1921-930
  11. Wang X, Wang S, Lin R, Jiang X, Cheng Z, Turdi J, Ding J, Wu G, Lu X, Wen H. GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate. J Hum Hypertens, 2004, 18(9): 663-68 CrossRef
  
• 作者单位：Jianying Jing BS (1)
  Dan Wang BS (2)
  Yi Jiao MS (3)
  Xiaofeng Wang PhD (2)
  Hao Wen PhD (4)
  Renyong Lin PhD (4)
  Jianzhong Jin MS (2)
  Li Jin PhD (2)
  
  1. Department of Biology, School of Environment and Chemical Engineering, Luoyang University, Luoyang, 471000, China
  2. Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, China
  3. Department of Biochemical and Molecular Biology, Xinjiang Medical University, Urumqi, 830054, China
  4. Central Laboratory, the First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830054, China
  

文摘

The relationship between the tenth exon C825T of G-protein β3 subunit (GNB3) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study (n = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB3 C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB3 C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups (χ 2 = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference (χ 2 = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB3 C825T polymorphism and hypertension in the Uygur population of China.