The effects of nutritional polyunsaturated fatty acids on locomotor activity in spontaneously hypertensive rats

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• 作者：Joachim Hauser (1)
  Ewelina Makulska-Gertruda (1)
  Andreas Reissmann (1)
  Thomas-A. Sontag (1)
  Oliver Tucha (2)
  Klaus W. Lange (1)
  
• 关键词：Spontaneously hypertensive rat ; SHR ; Animal model ; Nutrition ; Polyunsaturated fatty acid ; PUFA ; Omega ; 3 fatty acid ; Attention ; deficit/hyperactivity disorder ; ADHD
• 刊名：ADHD Attention Deficit and Hyperactivity Disorders
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：6
• 期：2
• 页码：61-65
• 全文大小：
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• 作者单位：Joachim Hauser (1)
  Ewelina Makulska-Gertruda (1)
  Andreas Reissmann (1)
  Thomas-A. Sontag (1)
  Oliver Tucha (2)
  Klaus W. Lange (1)
  
  1. Department of Experimental Psychology, University of Regensburg, 93040, Regensburg, Germany
  2. Department Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands
  
• ISSN：1866-6647

文摘

The present study investigated the effects of nutritional omega-3 polyunsaturated fatty acids on locomotor activity in spontaneously hypertensive rats (SHRs), which are used as an animal model of attention-deficit/hyperactivity disorder (ADHD). For 6?weeks, two groups of randomly assigned SHRs received food either enriched with or deficient in omega-3 fatty acids (based on the American Institute of Nutrition-3 G/AIN93G). Using an open field, locomotor activity was subsequently assessed for 6?days. A marked difference in locomotor activity as assessed by the distance travelled in the open field was found between the two groups of rats. In comparison with rats fed with omega-3 fatty acid-enriched food, the animals on the omega-3 fatty acid-deficient diet showed a significantly higher locomotor activity. The present findings demonstrated that nutritional enrichment with omega-3 fatty acids was associated with reduced motor activity in an established animal model of ADHD and support the notion that omega-3 polyunsaturated fatty acids may play a role in the pathophysiology of ADHD.