Systematic review of agents for the management of gastrointestinal mucositis in cancer patients

详细信息    查看全文

• 作者：Rachel J. Gibson (1)
  Dorothy M. K. Keefe (2) (3)
  Rajesh V. Lalla (4)
  Emma Bateman (2)
  Nicole Blijlevens (5)
  Margot Fijlstra (6)
  Emily E. King (4)
  Andrea M. Stringer (7)
  Walter J. F. M. van der Velden (5)
  Roger Yazbeck (7)
  Sharon Elad (8)
  Joanne M. Bowen (1)
  
• 关键词：Mucositis ; Guidelines ; Clinical management ; Gastrointestinal
• 刊名：Supportive Care in Cancer
• 出版年：2013
• 出版时间：January 2013
• 年：2013
• 卷：21
• 期：1
• 页码：313-326
• 全文大小：256KB
• 参考文献：1. Sonis ST et al (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100(9):1995鈥?025 CrossRef
  2. Krishna SG et al (2011) Incidence and risk factors for lower alimentary tract mucositis after 1529 courses of chemotherapy in a homogenous population of oncology patients: clinical and research implications. Cancer 117(3):648鈥?55 CrossRef
  3. Elting LS et al (2003) The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 98(7):1531鈥?539 CrossRef
  4. Elting LS et al (2007) Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. Int J Radiat Oncol Biol Phys 68(4):1110鈥?120 CrossRef
  5. Gibson RJ, Keefe DM (2006) Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies. Support Care Cancer 14(9):890鈥?00 CrossRef
  6. Sonis ST (1998) Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol 34(1):39鈥?3 CrossRef
  7. Rubenstein EB et al (2004) Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 100(9):2026鈥?046 CrossRef
  8. Sonis ST (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100(9):1995鈥?025 CrossRef
  9. Keefe DM (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109(5):820鈥?31 CrossRef
  10. Keefe DM (2004) Gastrointestinal mucositis: a new biological model. Support Care Cancer 12(1):6鈥? CrossRef
  11. Somerfield M et al (2000) ASCO clinical practice guidelines: process, progress, pitfalls, and prospects. Class Pap Curr Comm 4(4):881鈥?86
  12. Hadorn DC, Baker D, Hodges JS, Hicks N (1996) Rating the quality of evidence for clinical practice guidelines. J Clin Epidemiol 49(7):749鈥?54 CrossRef
  13. Delia P et al (2002) Prevention of radiation-induced diarrhea with the use of VSL#3, a new high-potency probiotic preparation. Am J Gastroenterol 97(8):2150鈥?512 CrossRef
  14. Osterlund P et al (2007) / Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer 97(8):1028鈥?034 CrossRef
  15. Urbancsek H et al (2001) Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus in patients with radiation-induced diarrhoea. Eur J Gastroenterol Hepatol 13(4):391鈥?96 CrossRef
  16. Koukourakis MI et al (2007) Hypofractionated accelerated radiochemotherapy with cytoprotection (Chemo-HypoARC) for inoperable non-small cell lung carcinoma. Anticancer Res 27(5B):3625鈥?631
  17. Han HS et al (2008) Randomized phase 2 study of subcutaneous amifostine versus epoetin-alpha given 3 times weekly during concurrent chemotherapy and hyperfractionated radiotherapy for limited-disease small cell lung cancer. Cancer 113(7):1623鈥?631 CrossRef
  18. Movsas B et al (2005) Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: radiation therapy oncology group trial 98-01. J Clin Oncol 23(10):2145鈥?154 CrossRef
  19. Komaki R et al (2002) Randomized phase III study of chemoradiation with or without amifostine for patients with favorable performance status inoperable stage II鈥揑II non-small cell lung cancer: preliminary results. Sem Rad Onc 12(1 Suppl 1):46鈥?9
  20. Baughan CA et al (1993) A randomized trial to assess the efficacy of 5-aminosalicylic acid for the prevention of radiation enteritis. Clin Oncol (R Coll Radiol) 5(1):19鈥?4 CrossRef
  21. Martenson JA Jr et al (1996) Olsalazine is contraindicated during pelvic radiation therapy: results of a double-blind, randomized clinical trial. Int J Radiat Oncol Biol Phys 35(2):299鈥?03 CrossRef
  22. Resbeut M et al (1997) A randomized double blind placebo controlled multicenter study of mesalazine for the prevention of acute radiation enteritis. Radiother Oncol 44(1):59鈥?3 CrossRef
  23. Shukla P et al (2010) Circadian variation in radiation-induced intestinal mucositis in patients with cervical carcinoma. Cancer 116(8):2031鈥?035 CrossRef
  24. Hille A et al (2005) A phase III randomized, placebo-controlled, double-blind study of misoprostol rectal suppositories to prevent acute radiation proctitis in patients with prostate cancer. Int J Radiat Oncol Biol Phys 63(5):1488鈥?493 CrossRef
  25. Kertesz T et al (2009) Effect of a prostaglandin鈥攇iven rectally for prevention of radiation-induced acute proctitis鈥攐n late rectal toxicity. Results of a phase III randomized, placebo-controlled, double-blind study. Strah Onkol 185(9):596鈥?02 CrossRef
  26. Blijlevens NM et al (2005) A randomised, double-blinded, placebo-controlled, pilot study of parenteral glutamine for allogeneic stem cell transplant patients. Support Care Cancer 13(10):790鈥?96 CrossRef
  27. Sornsuvit C et al (2008) Pilot Study: effects of parenteral glutamine dipeptide supplementation on neutrophil functions and prevention of chemotherapy-induced side-effects in acute myeloid leukaemia patients. J Int Med Res 36(6):1383鈥?391
  28. Li Y et al (2006) Oral glutamine ameliorates chemotherapy-induced changes of intestinal permeability and does not interfere with the antitumor effect of chemotherapy in patients with breast cancer: a prospective randomized trial. Tumori 92(5):396鈥?01
  29. Delia P et al (2007) Use of probiotics for prevention of radiation-induced diarrhea. World J Gastroenterol 13(6):912鈥?15
  30. Giralt J et al (2008) Effects of probiotic / Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial. Int J Radiat Oncol Biol Phys 71(4):1213鈥?219 CrossRef
  31. Syndman DR (2008) The safety of probiotics. Clin Infect Dis 46(2):104鈥?11. doi:2 CrossRef
  32. Ijiri K, Potten CS (1988) Circadian rhythms in the incidence of apoptotic cells and number of clonogenic cells in intestinal crypts after radiation using normal and reversed light conditions. Int J Radiat Biol Relat Stud Phys Chem Med 53(5):717鈥?27 CrossRef
  33. Tomita M et al (1990) Effect of ethanol on fatal carbon monoxide poisoning in awake mice [correction of rats]. Toxicol Lett 50(2鈥?):151鈥?57
  34. Richter J et al (1996) Reversibility of lower reproductive tract abnormalities in women with / Schistosoma haematobium infection after treatment with praziquantel鈥攁n interim report. Acta Trop 62(4):289鈥?01 CrossRef
  35. Michael M et al (2004) Phase II study of activated charcoal to prevent irinotecan-induced diarrhea. J Clin Oncol 22(21):4410鈥?417 CrossRef
  36. Sergio GC, Felix GM, Luis JV (2008) Activated charcoal to prevent irinotecan-induced diarrhea in children. Ped Blood Cancer 51(1):49鈥?2 CrossRef
  37. Gridelli C et al (2000) Thoracic radiotherapy and daily vinorelbine as radiosensitizer in locally advanced non small cell lung cancer: a phase I study. Lung Cancer 29(2):131鈥?37 CrossRef
  38. Garces YI et al (2007) Phase I North Central Cancer Treatment Group Trial-N9923 of escalating doses of twice-daily thoracic radiation therapy with amifostine and with alternating chemotherapy in limited stage small-cell lung cancer. Int J Radiat Oncol Biol Phys 67(4):995鈥?001 CrossRef
  39. Koukourakis MI et al (2002) Concurrent administration of Docetaxel and stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer: excellent tolerance using subcutaneous amifostine for cytoprotection. Review 38 refs. Br J Cancer 87(4):385鈥?92 CrossRef
  40. Antonadou D et al (2001) Randomized phase III trial of radiation treatment鈥?/鈭掆€塧mifostine in patients with advanced-stage lung cancer. Int J Radiat Oncol Biol Phys 51(4):915鈥?22, Erratum appears in Int J Radiat Oncol Biol Phys 2002 Apr 1;52(5):1458. Erratum appears in Int J Radiat Oncol Biol Phys 2002 Sep 1;54(1):308 CrossRef
  41. Marina N et al (2005) Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a children鈥檚 oncology group study. Cancer 104(4):841鈥?47 CrossRef
  42. Delioukina ML et al (2002) Phase II trial of irinotecan in combination with amifostine in patients with advanced colorectal carcinoma. Cancer 94(8):2174鈥?179 CrossRef
  43. Garcia-Manero G et al (2002) A phase I study of idarubicin dose escalation with amisfostine and high-dose cytarabine in patients with relapsed acute myelogenous leukemia and myelodysplastic syndromes. Haematologica 87(8):804鈥?07
  44. Arquette M et al (2002) Phase II evaluation of amifostine as an esophageal mucosal protectant in the treatment of limited-stage small cell lung cancer with chemotherapy and twice-daily radiation. Sem Radiat Oncol 12(1 Suppl 1):59鈥?1 CrossRef
  45. Leong SS et al (2003) Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable stage III non-small-cell lung cancer. J Clin Oncol 21(9):1767鈥?774 CrossRef
  46. Antonadou D et al (2003) Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 57(2):402鈥?08 CrossRef
  47. Capelli D et al (2000) Amifostine can reduce mucosal damage after high-dose melphalan conditioning for peripheral blood progenitor cellautotransplant: a retrospective study. Br J Haematol 110(2):300鈥?07 CrossRef
  48. Dunst J et al (2001) Intermittent use of amifostine during postoperative radiochemotherapy and acute toxicity in rectal cancer patients. Strahlenther Onkol 176(9):416鈥?21 CrossRef
  49. Awasthy BS et al (2001) Effect of amifostine on toxicities associated with salvage combination chemotherapy. J Assoc Physic India 49:236鈥?39
  50. Werner-Wasik M et al (2001) Preliminary report on reduction of esophagitis by amifostine in patients with non-small-cell lung cancer treated with chemoradiotherapy. Clin Lung Can 2(4):284鈥?89, discussion 290 CrossRef
  51. Tsavaris N et al (2003) Amifostine, in a reduced dose, protects against severe diarrhea associated with weekly fluorouracil and folinic acid chemotherapy in advanced colorectal cancer: a pilot study. J Pain Symptom Manage 26(3):849鈥?54 CrossRef
  52. Singh AK et al (2006) Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study. Int J Radiat Oncol Biol Phys 65(4):1008鈥?013 CrossRef
  53. Simone NL et al (2008) Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. Int J Radiat Oncol Biol Phys 70(1):90鈥?5 CrossRef
  54. Ben-Josef E et al (2002) A pilot study of topical intrarectal application of amifostine for prevention of late radiation rectal injury. Int J Radiat Oncol Biol Phys 53(5):1160鈥?164 CrossRef
  55. Takeda Y et al (2005) A phase I/II trial of irinotecan-cisplatin combined with an anti-late-diarrhoeal programme to evaluate the safety and antitumour response of this combination therapy in patients with advanced non-small-cell lung cancer. Br J Cancer 93(12):1341鈥?349 CrossRef
  56. Ando M et al (2004) Weekly administration of irinotecan (CPT-11) plus cisplatin for refractory or relapsed small cell lung cancer. Lung Cancer 44(1):121鈥?27 CrossRef
  57. Jahraus CD et al (2005) Prevention of acute radiation-induced proctosigmoiditis by balsalazide: a randomized, double-blind, placebo controlled trial in prostate cancer patients. Int J Radiat Oncol Biol Phys 63(5):1483鈥?487 CrossRef
  58. Karthaus M et al (2005) Prospective, double-blind, placebo-controlled, multicenter, randomized phase III study with orally administered budesonide for prevention of irinotecan (CPT-11)-induced diarrhea in patients with advanced colorectal cancer. Oncology 68(4鈥?):326鈥?32 CrossRef
  59. Lenfers BH et al (1999) Substantial activity of budesonide in patients with irinotecan (CPT-11) and 5-fluorouracil induced diarrhea and failure of loperamide treatment. Ann Oncol 10(10):1251鈥?253 CrossRef
  60. Furman WL et al (2006) Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors. J Clin Oncol 24(4):563鈥?70 CrossRef
  61. Wirth LJ et al (2005) Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 23(28):6976鈥?981 CrossRef
  62. Villalona-Calero M et al (2007) Thalidomide and celecoxib as potential modulators of irinotecan鈥檚 activity in cancer patients. Cancer Chemother Pharmacol 59(1):23鈥?3 CrossRef
  63. Dy GK et al (2005) A phase I trial of celecoxib in combination with docetaxel and irinotecan in patients with advanced cancer. Cancer Chemother Pharmacol 56(6):623鈥?28 CrossRef
  64. Argiris A et al (2006) Phase I and pharmacokinetic study of docetaxel, irinotecan, and celecoxib in patients with advanced non-small cell lung cancer. Invest New Drugs 24(3):203鈥?12 CrossRef
  65. Javle MM et al (2007) Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil. Clin Cancer Res 13(3):965鈥?71 CrossRef
  66. Flieger D et al (2007) Phase II clinical trial for prevention of delayed diarrhea with cholestyramine/levofloxacin in the second-line treatment with irinotecan biweekly in patients with metastatic colorectal carcinoma. Oncology 72(1鈥?):10鈥?6 CrossRef
  67. Heusinkveld RS, Manning MR, Aristizabal SA (1978) Control of radiation-induced diarrhea with cholestyramine. Int J Radiat Oncol Biol Phys 4(7鈥?):687鈥?90 CrossRef
  68. Chary S, Thomson DH (1984) A clinical trial evaluating cholestyramine to prevent diarrhea in patients maintained on low-fat diets during pelvic radiation therapy. Int J Radiat Oncol Biol Phys 10(10):1885鈥?890 CrossRef
  69. Tobin PJ et al (2006) A pilot study on the safety of combining chrysin, a non-absorbable inducer of UGT1A1, and irinotecan (CPT-11) to treat metastatic colorectal cancer. Cancer Chemother Pharmacol 57(3):309鈥?16 CrossRef
  70. Hrushesky WJ et al (1990) Circadian-shaped infusions of floxuridine for progressive metastatic renal cell carcinoma. J Clin Oncol 8(9):1504鈥?513
  71. Adler S et al (1994) Chronotherapy with 5-fluorouracil and folinic acid in advanced colorectal carcinoma. Results of a chronopharmacologic phase I trial. Cancer 73(12):2905鈥?912 CrossRef
  72. Depres-Brummer P et al (1995) Circadian rhythm-modulated (CRM) chemotherapy of metastatic breast cancer with mitoxantrone, 5-fluorouracil, and folinic acid: preliminary results of a phase I trial. J Infusl Chemother 5(3 Suppl 1):144鈥?47
  73. Price TJ et al (2004) Phase III study of mitomycin-C with protracted venous infusion or circadian-timed infusion of 5-fluorouracil in advanced colorectal carcinoma. Clinical Colo Cancer 3(4):235鈥?42 CrossRef
  74. Rajagopalan K, et al (1998鈥?999) Phase II trial of circadian infusion floxuridine (FUDR) in hormone refractory metastatic prostate cancer. Invest New Drugs. 16(3):255鈥?58
  75. Bertheault-Cvitkovic F et al (1993) Circadian rhythm-modulated chemotherapy with high-dose 5-fluorouracil: a pilot study in patients with pancreatic adenocarcinoma. Eur J Cancer 29A(13):1851鈥?854 CrossRef
  76. Conroy T et al (1993) Simplified chronomodulated continuous infusion of floxuridine in patients with metastatic renal cell carcinoma. Cancer 72(7):2190鈥?197 CrossRef
  77. Coudert B et al (2008) A randomized multicenter study of optimal circadian time of vinorelbine combined with chronomodulated 5-fluorouracil in pretreated metastatic breast cancer patients: EORTC trial 05971. Chronobiol Int 25(5):680鈥?96 CrossRef
  78. Tsujinaka S et al (2005) Formalin instillation for hemorrhagic radiation proctitis. Surg Innov 12(2):123鈥?28 CrossRef
  79. Algara M et al (2007) Prevention of radiochemotherapy-induced esophagitis with glutamine: results of a pilot study. Int J Radiat Oncol Biol Phys 69(2):342鈥?49 CrossRef
  80. Jazieh AR et al (2007) Phase I clinical trial of concurrent paclitaxel, carboplatin, and external beam chest irradiation with glutamine in patients with locally advanced non-small cell lung cancer. Cancer Invest 25(5):294鈥?98 CrossRef
  81. Muscaritoli M et al (1997) Oral glutamine in the prevention of chemotherapy-induced gastrointestinal toxicity. Eur J Cancer 33(2):319鈥?20 CrossRef
  82. Jebb SA, Marcus R, Elia M (1995) A pilot study of oral glutamine supplementation in patients receiving bone marrow transplants. Clin Nutr 14(3):162鈥?65 CrossRef
  83. Daniele B et al (2001) Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut 48(1):28鈥?3 CrossRef
  84. Canovas G et al (2000) Oral glutamine supplements in autologous hematopoietic transplant: impact on gastrointestinal toxicity and plasma protein levels. Haematologica 85(11):1229鈥?230
  85. Bozzetti F et al (1997) Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 13(7鈥?):748鈥?51 CrossRef
  86. Coghlin Dickson TM et al (2000) Effect of oral glutamine supplementation during bone marrow transplantation. Jpen: J Parenter Enter Nutr 24(2):61鈥?6 CrossRef
  87. Pytlik R et al (2002) Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study. Bone Marrow Transplant 30(12):953鈥?61 mt.1703759">CrossRef
  88. Kernstine KH et al (2005) Hyperbaric oxygen treatment of hemorrhagic radiation-induced gastritis after esophagectomy. Ann Thor Surg 80(3):1115鈥?117 CrossRef
  89. Jones K et al (2006) Treatment of radiation proctitis with hyperbaric oxygen. Radiother Oncol 78(1):91鈥?4 CrossRef
  90. Fink D et al (2006) Hyperbaric oxygen therapy for delayed radiation injuries in gynecological cancers. Int J Gynecol Cancer 16(2):638鈥?42 CrossRef
  91. Huddy JE et al (2006) Hyperbaric oxygen as a treatment for malabsorption in a radiation-damaged short bowel. Eur J Gastroenterol Hepatol 18(6):685鈥?88 CrossRef
  92. Dall鈥橢ra MA et al (2006) Hyperbaric oxygen therapy for radiation induced proctopathy in men treated for prostate cancer. J Urol 176(1):87鈥?0 CrossRef
  93. Girnius S et al (2006) Treatment of refractory radiation-induced hemorrhagic proctitis with hyperbaric oxygen therapy. Am J Clin Oncol 29(6):588鈥?92 CrossRef
  94. Safra T et al (2008) Improved quality of life with hyperbaric oxygen therapy in patients with persistent pelvic radiation-induced toxicity. Clinical Oncol (R Coll Radiol) 20(4):284鈥?87 CrossRef
  95. Sidik S et al (2007) Does hyperbaric oxygen administration decrease side effect and improve quality of life after pelvic radiation? Acta Med Indones 39(4):169鈥?73
  96. Woo TC, Joseph D, Oxer H (1997) Hyperbaric oxygen treatment for radiation proctitis. Int J Radiat Oncol Biol Phys 38(3):619鈥?22 CrossRef
  97. Mayer R et al (2001) Hyperbaric oxygen鈥攁n effective tool to treat radiation morbidity in prostate cancer. Radiother Oncol 61(2):151鈥?56 CrossRef
  98. Bui QC et al (2004) The efficacy of hyperbaric oxygen therapy in the treatment of radiation-induced late side effects. Int J Radiat Oncol Biol Phys 60(3):871鈥?78 CrossRef
  99. Bem J, Bem S, Singh A (2000) Use of hyperbaric oxygen chamber in the management of radiation-related complications of the anorectal region: report of two cases and review of the literature. Review 17 refs. Dis Col Rect 43(10):1435鈥?438 CrossRef
  100. Charneau J et al (1991) Severe hemorrhagic radiation proctitis advancing to gradual cessation with hyperbaric oxygen. Dig Dis Sci 36(3):373鈥?75 CrossRef
  101. Kitta T et al (2000) The treatment of chronic radiation proctitis with hyperbaric oxygen in patients with prostate cancer. BJU Inter 85(3):372鈥?74 CrossRef
  102. Bates TD (1969) The treatment of stage 3 carcinoma of the cervix by external radiotherapy and high-pressure oxygen. Br J Radiol 42(496):266鈥?69 CrossRef
  103. Jensen DM et al (1997) A randomized prospective study of endoscopic bipolar electrocoagulation and heater probe treatment of chronic rectal bleeding from radiation telangiectasia. Gastrointest Endo 45(1):20鈥?5 CrossRef
  104. Flombaum CD, Meyers PA (1999) High-dose leucovorin as sole therapy for methotrexate toxicity. J Clin Oncol 17(5):1589鈥?594
  105. Cavcic J et al (2000) Metronidazole in the treatment of chronic radiation proctitis: clinical trial. Croat Med J 41(3):314鈥?18
  106. Khan AM et al (2000) A prospective randomized placebo-controlled double-blinded pilot study of misoprostol rectal suppositories in the prevention of acute and chronic radiation proctitis symptoms in prostate cancer patients. Am J Gastroenterol 95(8):1961鈥?966 CrossRef
  107. de Jong FA et al (2006) Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study. Oncologist 11(8):944鈥?54 CrossRef
  108. Schmittel A et al (2004) Neomycin as secondary prophylaxis for irinotecan-induced diarrhea. Ann Oncol 15(8):1296 mdh310">CrossRef
  109. Alimonti A et al (2003) Prevention of irinotecan plus 5-fluorouracil/leucovorin-induced diarrhoea by oral administration of neomycin plus bacitracin in first-line treatment of advanced colorectal cancer. Ann Oncol 14(5):805鈥?06 mdg193">CrossRef
  110. Kehrer DF et al (2001) Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients. Clin Cancer Res 7(5):1136鈥?141
  111. Topkan E, Karaoglu A (2006) Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma. Oncology 71(5鈥?):354鈥?60 CrossRef
  112. Barbounis V et al (2001) Control of irinotecan-induced diarrhea by octreotide after loperamide failure. Support Care Cancer 9(4):258鈥?60 CrossRef
  113. Gebbia V et al (1993) Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy. Anti-Can Drugs 4(4):443鈥?45 CrossRef
  114. Cascinu S et al (1992) Control of chemotherapy-induced diarrhoea with octreotide in patients receiving 5-fluorouracil. Eur J Cancer 28(2鈥?):482鈥?83 CrossRef
  115. Zidan J et al (2001) Octreotide in the treatment of severe chemotherapy-induced diarrhea. Ann Oncol 12(2):227鈥?29 CrossRef
  116. Cascinu S et al (1993) Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial. J Clin Oncol 11(1):148鈥?51
  117. Geller RB et al (1995) Randomized trial of loperamide versus dose escalation of octreotide acetate for chemotherapy-induced diarrhea in bone marrow transplant and leukemia patients. Am J Hematol 50(3):167鈥?72 CrossRef
  118. Rosenoff S (2004) Resolution of refractory chemotherapy-induced diarrhea (CID) with octreotide long-acting formulation in cancer patients: 11 case studies. Support Care Cancer 12(8):561鈥?70 CrossRef
  119. Pro B, Lozano R, Ajani JA (2001) Therapeutic response to octreotide in patients with refractory CPT-11 induced diarrhea. Invest New Drugs 19(4):341鈥?43 CrossRef
  120. Rosen LS et al (2006) Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy. J Clin Oncol 24(33):5194鈥?200 CrossRef
  121. Johansson JE et al (2009) Gut protection by palifermin during autologous haematopoietic SCT. Bone Marrow Transplant 43(10):807鈥?11 mt.2008.388">CrossRef
  122. Andersen C et al (2006) The effect of a multidimensional exercise programme on symptoms and side-effects in cancer patients undergoing chemotherapy鈥攖he use of semi-structured diaries. Eur J Oncol Nurs 10(4):247鈥?62 CrossRef
  123. Jarden M et al (2009) A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant 43(9):725鈥?37 mt.2009.27">CrossRef
  124. Dimeo F et al (1997) Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 90(9):3390鈥?394
  125. DeNysschen CA et al (2011) Nutritional symptom and body composition outcomes of aerobic exercise in women with breast cancer. Clin Nurs Res 20(1):29鈥?6 CrossRef
  126. Abd El-Atti S et al (2009) Use of probiotics in the management of chemotherapy-induced diarrhea: a case study. JPEN J Parenter Enter Nutr 33(5):569鈥?70 CrossRef
  127. Chitapanarux I et al (2010) Randomized controlled trial of live / Lactobacillus acidophilus plus / Bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. Radiat Oncol 5:31 CrossRef
  128. Benchimol EI, Mack DR (2004) Probiotics in relapsing and chronic diarrhea. J Ped Hematol Oncol 26(8):515鈥?17 mph.0000133291.11443.a1">CrossRef
  129. Delia P et al (2002) Prophylaxis of diarrhoea in patients submitted to radiotherapeutic treatment on pelvic district: personal experience. Dig Liver Dis 34(Suppl 2):S84鈥揝86 CrossRef
  130. Hille A et al (2008) Sodium butyrate enemas in the treatment of acute radiation-induced proctitis in patients with prostate cancer and the impact on late proctitis. A prospective evaluation. Strahlenther und Onkol 184(12):686鈥?92 CrossRef
  131. Vernia P et al (2000) Topical butyrate for acute radiation proctitis: randomised, crossover trial. Lancet 356(9237):1232鈥?235 CrossRef
  132. Martenson JA et al (2000) Sucralfate in the prevention of treatment-induced diarrhea in patients receiving pelvic radiation therapy: a north central cancer treatment group phase III double-blind placebo-controlled trial. J Clin Oncol 18(6):1239鈥?245
  133. Henriksson R, Franzen L, Littbrand B (1991) Prevention of irradiation-induced bowel discomfort by sucralfate: a double-blind, placebo-controlled study when treating localized pelvic cancer. Am J Med 91(2A):151S鈥?57S CrossRef
  134. Duffour J et al (2002) Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer. Anticancer Res 22(6B):3727鈥?731, Erratum appears in Anticancer Res. 2003 Mar鈥揂pr;23(2B): following 1648. Erratum appears in Anticancer Res. 2003;23:5369
  135. Franzen L et al (1988) Managing side-effects in radiotherapy with regard to the gastrointestinal tract. Rec Res Cancer Res 108:127鈥?33 CrossRef
  136. Castagna L et al (2001) Prevention of mucositis in bone marrow transplantation: a double blind randomised controlled trial of sucralfate. Ann Oncol 12(7):953鈥?551 CrossRef
  137. Kneebone A et al (2001) The effect of oral sucralfate on the acute proctitis associated with prostate radiotherapy: a double-blind, randomized trial. Intl J Radiat Oncol Biol Phys 51(3):628鈥?35 CrossRef
  138. Stellamans K et al (2002) Does sucralfate reduce early side effects of pelvic radiation? A double-blind randomized trial. Radiother Oncol 65(2):105鈥?08 CrossRef
  139. Kochhar R et al (1991) Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate. Dig Dis Sci 36(1):103鈥?07 CrossRef
  140. O鈥橞rien PC et al (1997) A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis. Radiother Oncol 45(2):117鈥?23 CrossRef
  141. Kochhar R et al (1999) Natural history of late radiation proctosigmoiditis treated with topical sucralfate suspension. Dig Dis Sci 44(5):973鈥?78 CrossRef
  142. Melko GP et al (1999) Treatment of radiation-induced proctitis with sucralfate enemas. Ann Pharmacother 33(12):1274鈥?276 CrossRef
  143. O鈥橞rien PC et al (2002) Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis: longer term follow-up of a phase III trial鈥擳rans-Tasman Radiation Oncology Group. Int J Radiat Oncol Biol Phys 54(2):442鈥?49 CrossRef
  144. Gul YA et al (2002) Pharmacotherapy for chronic hemorrhagic radiation proctitis. World J Surg 26(12):1499鈥?502 CrossRef
  145. Sanguineti G et al (2003) Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study. Strahlenther Onkol 179(7):464鈥?704
  146. Chun M et al (2004) Rectal bleeding and its management after irradiation for uterine cervical cancer. Int J Radiat Oncol Biol Phys 58(1):98鈥?05 CrossRef
  147. Kilic D et al (2000) Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy. Radiother Oncol 57(2):125鈥?29 CrossRef
  148. Kilic D et al (2001) Sulfasalazine decreases acute gastrointestinal complications due to pelvic radiotherapy. Ann Pharmacother 35(7鈥?):806鈥?10 CrossRef
  
• 作者单位：Rachel J. Gibson (1)
  Dorothy M. K. Keefe (2) (3)
  Rajesh V. Lalla (4)
  Emma Bateman (2)
  Nicole Blijlevens (5)
  Margot Fijlstra (6)
  Emily E. King (4)
  Andrea M. Stringer (7)
  Walter J. F. M. van der Velden (5)
  Roger Yazbeck (7)
  Sharon Elad (8)
  Joanne M. Bowen (1)
  
  1. School of Medical Sciences, University of Adelaide, North Terrace, Adelaide, 5005, South Australia, Australia
  2. School of Medicine, University of Adelaide, Adelaide, Australia
  3. Royal Adelaide Hospital, Adelaide, Australia
  4. Section of Oral Medicine, University of Connecticut Health Centre, Farmington, CT, USA
  5. Department of Hematology, Radboud University, Nijmegen, The Netherlands
  6. Department of Pediatric Gastroenterology and Hepatology and Pediatric Oncology, Beatrix Children鈥檚 Hospital/Groningen University Medical Centre, Groningen, The Netherlands
  7. School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia
  8. Division of Oral Medicine Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA
  
• ISSN：1433-7339

文摘

Purpose The aim of this study was to review the available literature and define clinical practice guidelines for the use of agents for the prevention and treatment of gastrointestinal mucositis. Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. Results A total of 251 clinical studies across 29 interventions were examined. Panel members were able to make one new evidence-based negative recommendation; two new evidence-based suggestions, and one evidence-based change from previous guidelines. Firstly, the panel recommends against the use of misoprostol suppositories for the prevention of acute radiation-induced proctitis. Secondly, the panel suggests probiotic treatment containing Lactobacillus spp., may be beneficial for prevention of chemotherapy and radiotherapy-induced diarrhea in patients with malignancies of the pelvic region. Thirdly, the panel suggests the use of hyperbaric oxygen as an effective means in treating radiation-induced proctitis. Finally, new evidence has emerged which is in conflict with our previous guideline surrounding the use of systemic glutamine, meaning that the panel is unable to form a guideline. No guideline was possible for any other agent, due to inadequate and/or conflicting evidence. Conclusions This updated review of the literature has allowed new recommendations and suggestions for clinical practice to be reached. This highlights the importance of regular updates.