Hepatitis C virus genotypes in Kenya

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• 作者：Joseph Mwangi ; Zipporah Nganga ; Solomon Mpoke ; Raphael Lihana…
• 刊名：Archives of Virology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：161
• 期：1
• 页码：95-101
• 全文大小：413 KB
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• 作者单位：Joseph Mwangi (1) (4)
  Zipporah Nganga (4)
  Solomon Mpoke (2)
  Raphael Lihana (1)
  Joyceline Kinyua (1)
  Nancy Lagat (1)
  Joseph Muriuki (1)
  Rency Lel (1)
  Sheila Kageha (1)
  Saida Osman (1)
  Hiroshi Ichimura (3)
  
  1. Center for Virus Research, Kenya Medical Research Institute, P.O. Box 54628, Nairobi, Kenya
  4. Institute of Tropical Medicine and Infectious Disease, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
  2. Kenya Medical Research Institute, Nairobi, Kenya
  3. Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Virology
  Medical Microbiology
  Infectious Diseases
  
• 出版者：Springer Wien
• ISSN：1432-8798

文摘

Hepatitis C virus is a great public-health concern worldwide. Phylogenetic analysis of the HCV genome has identified six different genotypes that have generally been divided into several subtypes. There is very little information on HCV seroprevalence and genotypes in Kenya. To determine the genotypes of HCV circulating in Kenya, blood donor samples were serologically tested and confirmed by polymerase chain reaction (PCR). Positive samples were cloned and sequenced, and phylogenetic analysis conducted to determine the HCV genotypes. One hundred Murex-seropositive samples were re-tested using a passive hemagglutination test, and 16 of these were identified as seropositive. Further testing of all of the samples by PCR identified only 10 of the 16 samples as positive. Thus, only 10 % (10/100) of the samples were viremic. Six were from females (60 %), and four were from males (40 %). The mean age of the positive donors was considerably low, at 25 +/- 9 years. Genotypic testing indicated the presence of genotype 1a (10 %) and genotype 2b (90 %). This study reports on HCV genotypes in a blood donor population in Kenya where little had been done to provide information on HCV genotypes.