Enhancement of Solubility and Dissolution Rate of Loratadine with Gelucire 50/13

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• 作者：Suresh Bandari (1)
  Subash Jadav (1)
  Basanth Babu Eedara (1)
  Rajeshri Dhurke (1)
  Raju Jukanti (1)
  
• 关键词：Loratadine ; Gelucire 50/13 ; Phase solubility ; Solid dispersion ; Dissolution
• 刊名：Journal of Pharmaceutical Innovation
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：9
• 期：2
• 页码：141-149
• 全文大小：
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• 作者单位：Suresh Bandari (1)
  Subash Jadav (1)
  Basanth Babu Eedara (1)
  Rajeshri Dhurke (1)
  Raju Jukanti (1)
  
  1. Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Warangal, 506001, Andhra Pradesh, India
  
• ISSN：1939-8042

文摘

The objective of the current investigation was to enhance the solubility and dissolution rate of loratadine using solid dispersions (SDs) with Gelucire 50/13. SDs of loratadine using Gelucire 50/13 as carrier were prepared by the solvent evaporation method, characterized for drug content, dissolution behavior, and physicochemical characteristics by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) studies. At 10?% concentration of Gelucire 50/13, the increase in solubility was around 100-fold compared with pure drug. The solubility of loratadine in the presence of Gelucire 50/13 in water showed linear increase with increasing concentrations of Gelucire indicating AL-type solubility diagrams. The mean dissolution time (MDT) of loratadine decreased after preparation of SDs with Gelucire 50/13 indicating increased dissolution rate. FTIR studies showed the stability of loratadine and the absence of a well-defined interaction. DSC and XRD studies revealed the amorphous state of loratadine in SDs which was further confirmed from SEM. From the dissolution parameters, it is evident that the solubility and dissolution rate of loratadine was enhanced by SDs with Gelucire 50/13.