Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report

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• 作者：Kazuhito Hatanaka (1)
  Akihide Tanimoto (1)
  Yoshihisa Umekita (1)
  Takako Yoshioka (1)
  Takuro Kanekura (2)
  
• 刊名：Diagnostic Pathology
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：5
• 期：1
• 全文大小：936KB
• 参考文献：1. van der Putte SC: Anogenital "sweat" glands. Histology and pathology of a gland that may mimic mammary glands. / Am J Dermatopathol 1991, 13:557-67. CrossRef
  2. Groscurth P: Anatomy of sweat glands. In / Hyperhidrosis and Botulinum Toxin in Dermatology. Curr Probl Dermatol. Edited by: Kreyden OP, Boni R, Burg G. Basel: Kager; 2002:1-. CrossRef
  3. Woodworth H Jr, Dockerty MB, Wilson RB, Pratt JH: Papillary hidradenoma of the vulva: a clinicopathologic study of 69 cases. / Am J Obstet Gynecol 1971, 110:501-08.
  4. Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R: Mammary-like gland adenoma of the vulva: review of 46 cases. / Pathology 2009, 41:372-78. CrossRef
  5. Nishie W, Sawamura D, Mayuzumi M, Takahashi S, Shimizu H: Hidradenoma papilliferum with mixed histopathology features of syringocystadenoma papilliferum and anogenital mammary-like glands. / J Cutan Pathol 2004, 31:561-64. CrossRef
  6. Weedon D: Apocrine tumors. In / Tumors of Weedon's Skin Pathology. 3rd edition. Edited by: Weedon D. New Yolk: Churchill-Livingstone Elsevier; 2010:779-94.
  7. Obaidat NA, Awamleh AA, Ghazarian DM: Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region. / Eur J Dermatol 2006, 16:576-78.
  8. Kazakov DV, Bisceglia M, Sima R, Michal M: Adenosis tumor of anogenital mammary-like glands: a case report and demonstration of clonality by HUMARA assay. / J Cutan Pathol 2006, 33:43-6. CrossRef
  9. Mazoujian G, Margolis R: Immunohistochemistry of gross cystic disease fluid protein (GCDFP-15) in 65 benign sweat gland tumors of the skin. / Am J Dermatopathol 1988, 10:28-5. CrossRef
  10. Tubura A, Senzaki H, Sasaki M, Hilgers J, Morii S: Immunohistochemical demonstration of breast-derived and/or carcinoma-associated glycoproteins in normal skin appendages and their tumors. / J Cutan Pathol 1992, 19:73-9. CrossRef
  11. De Viraph PA, Szeimies RM, Eckert F: Apocrine cystadenoma, apocrine hidrocystoma, and eccrine hidrocystoma: three distinct tumors defined by expression of keratins and human milk fat globulin 1. / J Cutan Pathol 1997, 24:249-55. CrossRef
  12. Ohnishi T, Watanabe S: Immunohistochemical analysis of cytokeratin expression in apocrine cystadenoma or hidrocystoma. / J Cutan Pathol 1999, 26:295-00. CrossRef
  13. Swanson PE, Mazoujian G, Millis SE, Campbell RJ, Wick MR: Immunoreactivity for estrogen receptor protein in sweat gland tumors. / Am J Surg Pathol 1991, 15:835-41. CrossRef
  14. Otsuka T, Ueda Y, Terauchi M, Kinoshita Y: Median raphe (parameatal) cysts of the penis. / J Urol 1998, 159:1918-920. CrossRef
  15. Ohnishi T, Watanabe S: Immunohistochemical analysis of human milk fat globulin 1 and cytokeratins expression in median raphe cyst of the penis. / Clin Exp Dermatol 2001, 26:88-2. CrossRef
  
• 作者单位：Kazuhito Hatanaka (1)
  Akihide Tanimoto (1)
  Yoshihisa Umekita (1)
  Takako Yoshioka (1)
  Takuro Kanekura (2)
  
  1. Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan
  2. Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
  

文摘

A rare case of an apocrine tumor in the male perineal region is reported. A dermal cystic lesion developed in the region between the anus and scrotum of a 74-year-old Japanese male. The cystic lesion, measuring 3.5 × 5.0 cm in size, was lined by columnar or flattened epithelium with occasional apocrine features and supported by a basal myoepithelium lining. A mural nodule, measuring 1 × 1.5 cm in size, protruded into the cystic space and consisted of a solid proliferation of tubular glands with prominent apocrine secretion and basal myoepithelial cells. Immunohistochemical examination showed that the luminal cells were partially positive for gross cystic disease fluid protein 15 and human milk fat globulin 1, and the basal myoepithelial cells were positive for alpha-smooth muscle actin and S-100 protein. Estrogen and progesterone hormone receptors were focally and weakly positive for luminal epithelium. Although no mammary-like glands were present in the dermis around the tumor, this unusual apocrine tumor has been suggested to be derived from male anogenital mammary-like glands and mimic a mammary-like gland adenoma in the male perineum.