Targeted therapies for treatment of renal cell carcinoma: recent advances and future perspectives
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- 作者：Joan Minguet ; Katherine H. Smith…
- 关键词：Targeted therapy ; Tyrosine kinase inhibitors ; Mammalian target of rapamycin ; Angiogenesis ; Programmed death ; Antibodies
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2015
- 出版时间：August 2015
- 年：2015
- 卷：76
- 期：2
- 页码：219-233
- 全文大小：737 KB
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Katherine H. Smith (1)
Carsten P. Bramlage (2)
Peter Bramlage (1) (2)
1. European Institute of Cancer Research (EICR), Carrer del Passeig, 2, 08221, Terrassa, Spain
2. Institute of Pharmacology and Preventive Medicine (IPPMED), Bahnhofstr. 20, 49661, Cloppenburg, Germany - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Cancer Research
Pharmacology and Toxicology
Oncology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0843
文摘
Purpose A wide variety of targeted therapies are available for the treatment of renal cancer that has progressed beyond the point at which surgery is a viable option. In addition, there are many more that are in the different stages of clinical trials. Here, we provide a methodical discussion of the efficacy and safety of targeted therapies for the treatment of advanced renal cell carcinoma. Methods We conducted a systematic literature employing the search terms: renal cell carcinoma targets, tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors, and each of the drugs discussed within these papers. Results The identified targeted therapies work by disrupting specific signalling pathways involved in tumour progression, such as those responsible for angiogenesis and cell proliferation. Tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors are now established classes of drugs used in the treatment of renal cancer, with a total of six having received regulatory approval to date (sorafenib, sunitinib, pazopanib, axitinib, temsirolimus, and everolimus). Ongoing trials are likely to result in addition to these in the near future, for example, tivozanib, dovitinib, and cediranib. Furthermore, in addition to these small molecule drugs, immunotherapies involving monoclonal antibodies against signalling molecules such as vascular endothelial growth factor (bevacizumab) or programmed death-1 (nivolumab) are receiving increasing attention. Conclusions Targeted therapies have great potential for disrupting tumour progression by inhibiting certain signalling pathways. As our understanding of the biochemical pathways involved in cancer progresses, additional targets are certain to become apparent, expanding treatment options even further.