Preclinical in vivo and in vitro comparison of the translocator protein PET ligands [¹⁸F]PBR102 and [¹⁸F]PBR111

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• 作者：S. Eberl ; A. Katsifis ; M. A. Peyronneau…
• 关键词：TSPO ; [18F]PBR102 ; [18F]PBR111 ; Microsomes ; Metabolism ; Non ; human primate PET ; CT
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：44
• 期：2
• 页码：296-307
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1619-7089
• 卷排序：44

文摘

PurposeTo determine the metabolic profiles of the translocator protein ligands PBR102 and PBR111 in rat and human microsomes and compare their in vivo binding and metabolite uptake in the brain of non-human primates (Papio hamadryas) using PET-CT.