Investigation of gene–diet interactions in the incretin system and risk of type 2 diabetes: the EPIC-InterAct study

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• 关键词：Coffee ; Dairy ; Fibre ; Gene–environment interaction ; GIPR ; Incretins ; KCNQ1 ; Olive oil ; TCF7L2 ; WFS1
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：59
• 期：12
• 页码：2613-2621
• 全文大小：329 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428
• 卷排序：59

文摘

Aims/hypothesisThe gut incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) have a major role in the pathophysiology of type 2 diabetes. Specific genetic and dietary factors have been found to influence the release and action of incretins. We examined the effect of interactions between seven incretin-related genetic variants in GIPR, KCNQ1, TCF7L2 and WFS1 and dietary components (whey-containing dairy, cereal fibre, coffee and olive oil) on the risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study.